Cytogenetic biomonitoring of primary school children exposed to air pollutants: micronuclei analysis of buccal epithelial cells

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dc.authoridCAKMAK, GONCA/0000-0002-6283-5404
dc.authoridARI, AKIF/0000-0003-3870-8779
dc.authoridAltug, Hicran/0000-0001-9430-6155
dc.authoridBurgaz, Sema/0000-0002-9612-5769
dc.contributor.authorDemircigil, Gonca Cakmak
dc.contributor.authorErdem, Onur
dc.contributor.authorGaga, Eftade O.
dc.contributor.authorAltug, Hicran
dc.contributor.authorDemirel, Gulcin
dc.contributor.authorOzden, Ozlem
dc.contributor.authorAri, Akif
dc.date.accessioned2024-09-18T19:52:32Z
dc.date.available2024-09-18T19:52:32Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThere is an increasing attempt in the world to determine the exposures of children to environmental chemicals. To analyze the genotoxic effect of air pollution, micronucleus (MN) assay was carried out in buccal epithelial cells (BECs) of children living in an urban city of Turkey. Children from two schools at urban-traffic and suburban sites were investigated in summer and winter seasons for the determination of BEC-MN frequency (per mille) and frequency of BEC with MN (per mille). The same children were also recruited for lung function measurements within a MATRA project (Together Towards Clean Air in Eskisehir and Iskenderun) Measured NO2 and SO2 concentrations did not exceed the European Union (EU) limit levels either in urban-traffic or suburban regions. Higher O-3 concentrations were measured in the suburban site especially in the summer period. Particulate matter (PM2.5 and PM10) levels which did not differ statistically between two regions were above the EU limits in general. Although BEC-MN frequencies of children living in the suburban sites were higher in general, the difference between two regions was not significant either in the summer or winter periods. BEC-MN frequencies of the urban-traffic children were found to be significantly higher in summer period (mean +/- SD, 2.68 +/- 1.99) when compared to winter period (1.64 +/- 1.59; p = 0.004). On the other hand, no seasonality was observed for the suburban children. Similar results have been obtained in the BEC frequency with MN in our study. In summer, BEC-MN frequencies were significantly increased with the decrease in pulmonary function levels based on forced expiratory flow between 25 and 75 % of vital capacity (FEF25-75 %) levels (p < 0.05). As a conclusion, children living in urban-traffic and suburban areas in the city of EskiAYehir exhibited similar genotoxicity. Seasonal variation in genotoxicity may be interpreted as relatively high ozone levels and increasing time spent at outdoors in the summer.en_US
dc.description.sponsorshipDutch Ministry of Foreign Affairsen_US
dc.description.sponsorshipWe would like to thank Kees Meliefste and Institute for Risk Assessment Sciences for their support during field studies. We also thank very much to the school directors and teachers for their very valuable help during the sampling studies. The authors are grateful to the children and their parents for their participation in this study. We would also like to thank Mr. Salih Ergocen for performing the statistical analysis.; This study was part of the MATRA project Together Towards Clean Air in Eskisehir and Iskenderun financed by the Dutch Ministry of Foreign Affairs.en_US
dc.identifier.doi10.1007/s11356-013-2001-6
dc.identifier.endpage1207en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue2en_US
dc.identifier.pmid23884878en_US
dc.identifier.scopus2-s2.0-84891633281en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1197en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-013-2001-6
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7492
dc.identifier.volume21en_US
dc.identifier.wosWOS:000329243700038en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAir pollutionen_US
dc.subjectChildrenen_US
dc.subjectPersonal biomonitoringen_US
dc.subjectBuccal epithelial cellsen_US
dc.subjectMicronucleus assayen_US
dc.titleCytogenetic biomonitoring of primary school children exposed to air pollutants: micronuclei analysis of buccal epithelial cellsen_US
dc.typeArticleen_US

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