Effects of Paliperidone Palmitate on Coagulation: An Experimental Study

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dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.contributor.authorYilmaz, Enver Demirel
dc.contributor.authorMotor, Sedat
dc.contributor.authorSefil, Fatih
dc.contributor.authorPinar, Neslihan
dc.contributor.authorKokacya, Hanifi
dc.contributor.authorKisa, Mustafa
dc.contributor.authorOktar, Suleyman
dc.date.accessioned2024-09-18T21:06:27Z
dc.date.available2024-09-18T21:06:27Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective. The aim of the present study was to examine the effects of a new antipsychotic drug paliperidone palmitate on hemogram and coagulation parameters in rats. Materials and Methods. Experiments were performed on 22 female albino Wistar rats (8-12 weeks old). Control group was given drinking water as vehicle (0.3 mL). PAL-1 rats were given 1 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage once a day for ten days and PAL-3 rats received 3 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage for ten days. Blood samples were drawn from the heart 24 hours after the last drug dose, and hemogram and coagulation parameters were measured with automated analyzers. Results. Hemogram did not change in the paliperidone treated groups compared to the controls. Factor VIII levels decreased in the PAL-1 and PAL-3 groups; and this decrease was significantly greater in the PAL-3. Factor IX levels decreased in PAL-3 rats, but its levels also increased in PAL-1 rats compared to the control. Discussion. Paliperidone has led to changes in the serum levels of coagulation factors VIII and IX in rats. As a result, paliperidone may be causing thromboembolism or bleeding in a dose-independent manner.en_US
dc.identifier.doi10.1155/2014/964380
dc.identifier.issn1537-744X
dc.identifier.pmid24764772en_US
dc.identifier.scopus2-s2.0-84896355433en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1155/2014/964380
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13617
dc.identifier.wosWOS:000331756300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofScientific World Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVenous Thromboembolismen_US
dc.subjectSchizophrenia-Patientsen_US
dc.subjectRisperidoneen_US
dc.subjectAntipsychoticsen_US
dc.subjectRisken_US
dc.titleEffects of Paliperidone Palmitate on Coagulation: An Experimental Studyen_US
dc.typeArticleen_US

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