Effects of Intravenous Anesthetics on Renal Ischemia/Reperfusion Injury

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dc.authoridOzkan, Orhan Veli/0000-0002-2862-294X
dc.contributor.authorYuzer, Husamettin
dc.contributor.authorYuzbasioglu, Mehmet Fatih
dc.contributor.authorCiralik, Harun
dc.contributor.authorKurutas, Ergul Belge
dc.contributor.authorOzkan, Orhan Veli
dc.contributor.authorBulbuloglu, Ertan
dc.contributor.authorAtli, Yalcm
dc.date.accessioned2024-09-18T20:28:10Z
dc.date.available2024-09-18T20:28:10Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground. Renal ischemia/reperfusion (I/R)-induced tubular epithelial cell injury, called ischemic acute renal failure, is associated with high mortality in humans. Protecting the kidney against I/R injury is very important during complicated renal operations, transplantation surgery, and anesthesia. Aim. The purpose of this study was to investigate and compare the efficiency of ketamine, thiopental, propofol, etomidate, and intralipid in reducing the injury induced by free radicals in a rat model of renal I/R. Method. Forty-two Wistar rats were divided into seven groups in our study. Rats in the sham group underwent laparotomy and waited for 120 minutes (min) without ischemia. Rats in the control group were given nothing with ischemia-reperfusion. Rats in the I/R groups were given ketamine (20 mg/kg), thiopental (20 mg/kg) propofol (25 mg/kg), etomidate (10 mg/kg) and 10% intralipid (250 mg/kg) intraperitoneally 15 min prior to the ischemia for 60 min, followed by reperfusion for 60 min. The blood samples and kidney tissues of the rats were obtained under anesthesia at the end of the reperfusion period. Biochemical malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), blood urea nitrogen (BUN), creatine (Cr), aspartate aminotransferase (AST) were determined, and histopathological analysis was performed with these samples. Results. MDA level was increased significantly in the control group (p 0.05). Histopathological findings of the control group confirmed that there was renal impairment by tubular cell swelling, interstitial edema, medullary congestion, and tubular dilatation. MDA levels were lower in the ketamine, thiopental, and propofol groups compared to the control group (p 0.05). In the thiopental and propofol groups, the levels of histopathological scores were significantly lower than control and etomidate groups in ischemia-reperfusion. Conclusion. Our results demonstrated that I/R injury was significantly reduced in the presence of propofol and thiopental. The protective effects of these drugs may belong to their antioxidant properties. These results may indicate that propofol and thiopental anesthesia protects against functional, biochemical, and morphological damage better than control in renal I/R injury.en_US
dc.identifier.doi10.1080/08860220902779962
dc.identifier.endpage296en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue4en_US
dc.identifier.pmid19462278en_US
dc.identifier.scopus2-s2.0-67651146414en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage290en_US
dc.identifier.urihttps://doi.org/10.1080/08860220902779962
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10774
dc.identifier.volume31en_US
dc.identifier.wosWOS:000266279700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectischemia reperfusion injuryen_US
dc.subjectketamineen_US
dc.subjectthiopentalen_US
dc.subjectpropofolen_US
dc.subjectetomidateen_US
dc.titleEffects of Intravenous Anesthetics on Renal Ischemia/Reperfusion Injuryen_US
dc.typeArticleen_US

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