EVALUATION OF THE IN VITRO AND IN VIVO EFFECTS OF THE ETHANOLIC LYOPHILIZED EXTRACT OBTAINED FROM PHOLIOTA AURIVELLA MUSHROOM ON CCI4-INDUCED TOXICITY IN RATS

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dc.authoriddogan, abdulahad/0000-0002-5438-8560
dc.contributor.authorDogan, Abdulahad
dc.contributor.authorDalar, Abdullah
dc.contributor.authorBattal, Abdulhamit
dc.contributor.authorUyar, Ahmet
dc.contributor.authorSadullahoglu, Cemil
dc.contributor.authorCelik, Ismail
dc.contributor.authorUzun, Yusuf
dc.date.accessioned2024-09-18T20:54:12Z
dc.date.available2024-09-18T20:54:12Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate Pholiota aurivella extract's chemical and mineral composition, total antioxidant capacity, histopathological changes in liver and kidney, as well as its possible protective/harmful role against carbon tetrachloride (CCl4)-induced oxidative stress in rats. After the toxicity test, twenty four rats were divided into four experimental groups: Control, CCl4, CCl4+P. aurivella (100 mg/kg, extract) and CCl4+P.aurivella (500 mg/kg, extract) groups. Some biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) in serum, malondialdehyde (MDA) and antioxidant defense system (ADS) constituents such as reduced glutathione (GSH) levels, glutathione reductase (GR), glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities in the liver, brain and kidney tissues, histopathological changes in liver and kidney of rats were observed. P.aurivella extract was rich in phenolic (p-coumaric and protocatechuic acids) and fatty acid (linoleic, oleic and palmitic acids) compounds and high level of Arsenic. In vivo studies revealed that P.aurivella extract suppressed the levels of ADS enzymes and increased the MDA content and AST, ALT and LDH in treated groups. According to histopathological investigation, liver and kidney revealed severe histopathological changes both in CCl4 group and P.aurivella- treated groups. These results have shown that oral administration of P. aurivella extract caused a significant toxic effects in rats. Therefore, in the context of the data obtained from this study the P. aurivella could not be regarded as a safe food source.en_US
dc.description.sponsorshipUniversity of Van Yuzuncu Yil Grant Commission [THD-2016-5377]en_US
dc.description.sponsorshipThis paper is dedicated to the memory of Prof. Dr. Kenan Demirel. The all authors declare that there is no conflict of interest. The authors are grateful to the University of Van Yuzuncu Yil Grant Commission for providing financial assistance of the research (Project number: THD-2016-5377).en_US
dc.identifier.endpage9516en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue12en_US
dc.identifier.startpage9503en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11669
dc.identifier.volume28en_US
dc.identifier.wosWOS:000503915900060en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPholiota aurivellaen_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectBioactive compoundsen_US
dc.subjectOxidative stressen_US
dc.subjectHistopathological changesen_US
dc.subjectRatsen_US
dc.titleEVALUATION OF THE IN VITRO AND IN VIVO EFFECTS OF THE ETHANOLIC LYOPHILIZED EXTRACT OBTAINED FROM PHOLIOTA AURIVELLA MUSHROOM ON CCI4-INDUCED TOXICITY IN RATSen_US
dc.typeArticleen_US

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