Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats

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dc.authoriddikmen, nursel/0000-0002-5923-400X
dc.authoridEtyemez, Muhammed/0000-0003-0497-1878
dc.authoridAYDIN, TUBA/0000-0002-7653-6480
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.contributor.authorDikmen, Nursel
dc.contributor.authorCellat, Mustafa
dc.contributor.authorEtyemez, Muhammed
dc.contributor.authorIsler, Cafer Tayer
dc.contributor.authorUyar, Ahmet
dc.contributor.authorAydin, Tuba
dc.contributor.authorGuvenc, Mehmet
dc.date.accessioned2024-09-18T20:52:51Z
dc.date.available2024-09-18T20:52:51Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAcute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)-induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 h. The results showed that in the group treated with oleuropein, inflammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage fluid (BALF), and lung tissue, and there were significant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination. Based on the findings of the present study, oleuropein showed protective effects against LPS-induced ALI.en_US
dc.description.sponsorshipScientific Research Projects Coordination of Hatay Mustafa Kemal University [20]en_US
dc.description.sponsorshipThis study was financially supported by the Scientific Research Projects Coordination of Hatay Mustafa Kemal University (project number: 20.M.020).en_US
dc.identifier.doi10.1007/s10753-021-01496-x
dc.identifier.endpage2259en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue6en_US
dc.identifier.pmid34515957en_US
dc.identifier.startpage2246en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-021-01496-x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11449
dc.identifier.volume44en_US
dc.identifier.wosWOS:000695393800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectoleuropeinen_US
dc.subjectlung injuryen_US
dc.subjectlipopolysaccharideen_US
dc.titleAmeliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Ratsen_US
dc.typeArticleen_US

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