The protective effects of caffeic acid phenethyl ester against toluene-induced nephrotoxicity in rats

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dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.contributor.authorMeydan, Sedat
dc.contributor.authorNacar, Ahmet
dc.contributor.authorOzturk, Hasan Oktay
dc.contributor.authorTas, Ufuk
dc.contributor.authorKose, Evren
dc.contributor.authorZararsiz, Ismail
dc.contributor.authorYilmaz, Nigar
dc.date.accessioned2024-09-18T20:53:03Z
dc.date.available2024-09-18T20:53:03Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCaffeic acid phenethyl ester (CAPE) has antioxidant and anti-inflammatory properties. The aim of this study is to examine the negative effects of toluene on kidney tissues and functions and to investigate the protective effects of CAPE against toluene-induced nephrotoxicity in rats. A total of 21 male Wistar rats were divided into three groups of equal number in each. The rats in group I were the controls. Toluene was intraperitoneally injected into the rats in group II with a dose of 500 mg/kg. Rats in group III received CAPE daily while exposed to toluene. After 14 days of experimental period, all rats were killed by decapitation. Enzymatic activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) and malondialdehyde (MDA) levels were studied in the rat kidneys. Blood urea nitrogen (BUN) and serum creatinine levels were measured for renal function. The CAT and SOD enzyme activities and serum creatinine levels were significantly increased in rats treated with toluene when compared with the controls. But GSH-Px activity, MDA, and BUN levels showed statistically nonsignificant changes. However, increased CAT and SOD enzyme activities and decreased serum creatinine levels were detected in the rats that received CAPE while exposed to toluene. The GSH-Px activity and MDA and BUN levels in the same group did not show statistically significant changes. The results of our study demonstrated that toluene damages kidney tissue and is a nephrotoxic substance. CAPE was able to prevent the renal damage as antioxidant, antitoxic, and nephroprotective agent.en_US
dc.identifier.doi10.1177/0748233713485890
dc.identifier.endpage21en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue1en_US
dc.identifier.pmid23858052en_US
dc.identifier.scopus2-s2.0-84952921469en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.1177/0748233713485890
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11557
dc.identifier.volume32en_US
dc.identifier.wosWOS:000367580200003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative stressen_US
dc.subjecttolueneen_US
dc.subjectantioxidanten_US
dc.subjectrenalen_US
dc.subjectoccupational healthen_US
dc.titleThe protective effects of caffeic acid phenethyl ester against toluene-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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