The effect of Bongardia Chrysogonum on prostate tissue in a rat model of STZ-induced diabetes

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorGozukara, Kerem Han
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorSefil, Nebihat Kaplan
dc.contributor.authorNacar, Ahmet
dc.contributor.authorDokuyucu, Ahmet
dc.contributor.authorInci, Mehmet
dc.date.accessioned2024-09-18T20:15:09Z
dc.date.available2024-09-18T20:15:09Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Bongardia chrysogonum is widely used in Turkey for treating urinary tract infections and prostate hypertrophy, and it also has potent hypoglycemic effects and aids glucose homeostasis. Because of the inflammatory conditions in diabetes mellitus (DM), the prostate tissue of men with diabetes is particularly susceptible to developing hypoplasia, and DM produces characteristic pathological changes in prostate tissue. Here, we examined the effects of B. chrysogonum on the prostate tissue of rats with streptozotocin (STZ)-induced diabetes. Results: The glucose levels were statistically significantly higher in the diabetic rats than in healthy controls (P < 0.001). Further, they were significantly lower in the healthy and diabetic rats administered B. chrysogonum than in the untreated diabetic rats (P < 0.001 and 0.05, respectively). The total cholesterol levels were significantly lower in the healthy rats administered B. chrysogonum than the healthy controls (P < 0.05) and diabetic rats (P < 0.01). They were also significantly lower in the diabetic rats administered B. chrysogonum than those that were left untreated (P < 0.05). The testosterone levels were significantly lower in the untreated diabetic rats than in the controls (untreated ones and those administered B. chrysogonum) and diabetic rats administered the herb (P < 0.001, 0.05 and 0.01, respectively). The oxidative stress index was significantly higher in the untreated diabetic rats than the healthy controls (P < 0.05). It was also significantly lower in the healthy and diabetic groups treated with B. chrysogonum than the untreated diabetic rats (P < 0.05). Histological examination showed no changes in the prostate tissue of the non-diabetic rats. In the diabetic group, the glandular lumens were filled with cellular debris and leucocytic infiltrate, and the glandular epithelium was degenerated and thickened. In the diabetic group treated with B. chrysogonum, the epithelium was better preserved and less debris was seen in the glandular lumen. Conclusion: To our knowledge, this is the first study to histologically prove the effects of B. chrysogonum on prostate tissue in diabetes. Our findings may be useful in developing B. chrysogonum into a therapeutic agent against diabetes and benign prostate hyperplasia.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Projects Coordination Unit [12457]en_US
dc.description.sponsorshipThis study was funded by the Mustafa Kemal University Scientific Research Projects Coordination Unit. (Number: 12457).en_US
dc.identifier.doi10.1186/s40064-016-2973-z
dc.identifier.issn2193-1801
dc.identifier.pmid27563517en_US
dc.identifier.scopus2-s2.0-84981713332en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1186/s40064-016-2973-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9478
dc.identifier.volume5en_US
dc.identifier.wosWOS:000381642600007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer International Publishing Agen_US
dc.relation.ispartofSpringerplusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectProstateen_US
dc.subjectBongardia chrysogonumen_US
dc.subjectTestosteroneen_US
dc.subjectOxidative stressen_US
dc.subjectInflammationen_US
dc.titleThe effect of Bongardia Chrysogonum on prostate tissue in a rat model of STZ-induced diabetesen_US
dc.typeArticleen_US

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