Synergistic Effect of Omega-3 and Probiotic Supplementation on Preventing Ligature-Induced Periodontitis

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dc.authoridOzmen, Ozlem/0000-0002-1835-1082
dc.contributor.authorDogan, Burak
dc.contributor.authorKemer Dogan, Esra Sinem
dc.contributor.authorOzmen, Ozlem
dc.contributor.authorFentoglu, Ozlem
dc.contributor.authorKirzioglu, Fatma Yesim
dc.contributor.authorCalapoglu, Mustafa
dc.date.accessioned2024-09-18T19:54:15Z
dc.date.available2024-09-18T19:54:15Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOmega-3 and probiotics were shown to improve periodontal health by modulating the host immune response. Recently, the combination of omega-3 and probiotics has been shown to have a potential synergistic effect on host modulation. The aim of this study was to evaluate the prophylactic role of an omega-3 and probiotic combination on alveolar bone loss (ABL) via inflammatory response in an experimental periodontitis model. Forty-three rats were divided into 5 groups as control (C, n = 8), periodontitis (P, n = 8), omega-3 + periodontitis (O, n = 8), probiotic + periodontitis (Pro, n = 10), and omega-3 + probiotic + periodontitis (OPro, n = 9). Additionally to a standardized diet, omega-3 and/or probiotics were supplemented with oral gavage to the O, Pro, and OPro groups for 44 days. Periodontitis was induced by ligature to the P, O, Pro, and OPro groups on the 30th day for 2 weeks. ABL levels were measured histopathologically, and serum interleukin (IL) 1 beta, IL6, and IL10 levels were analysed by enzyme-linked immunosorbent assay. ABL increased in all periodontitis groups (P, O, Pro, and OPro), compared to C group. Compared to P group, all oral gavage groups (O, Pro, and OPro) revealed decreased ABL, which was lowest in OPro group. IL1 beta and IL6 decreased and IL10 increased in OPro group, compared to P group. In conclusion, prophylactic administration of omega-3 and probiotic combination reduced ABL and improved serum IL1 beta, IL6, and IL10 levels more than their single use.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Scientific Research Projects Commission [18.M.090]en_US
dc.description.sponsorshipThis study was financially supported by the Hatay Mustafa Kemal University Scientific Research Projects Commission (Project No. 18.M.090).en_US
dc.identifier.doi10.1007/s12602-021-09803-6
dc.identifier.endpage120en_US
dc.identifier.issn1867-1306
dc.identifier.issn1867-1314
dc.identifier.issue1en_US
dc.identifier.pmid34037942en_US
dc.identifier.scopus2-s2.0-85106531123en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://doi.org/10.1007/s12602-021-09803-6
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7597
dc.identifier.volume14en_US
dc.identifier.wosWOS:000654824900003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofProbiotics and Antimicrobial Proteinsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlveolar bone lossen_US
dc.subjectFatty acidsen_US
dc.subjectOmega 3en_US
dc.subjectInflammation mediatorsen_US
dc.subjectPeriodontitisen_US
dc.subjectProbioticsen_US
dc.titleSynergistic Effect of Omega-3 and Probiotic Supplementation on Preventing Ligature-Induced Periodontitisen_US
dc.typeArticleen_US

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