The Neuroprotective Effect of Caffeic Acid Phenethyl Ester on Global Ischemia-Reperfusion Injury in Rat Brains

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dc.contributor.authorAltug, Muhammed Enes
dc.contributor.authorMelek, Ismet M.
dc.contributor.authorErdogan, Suat
dc.contributor.authorDuzguner, Vesile
dc.contributor.authorOzturk, Atakan
dc.contributor.authorKucukgul, Altug
dc.date.accessioned2024-09-18T20:06:27Z
dc.date.available2024-09-18T20:06:27Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE) on phosphodiesterase 4 (PDE4) mRNA isoenzymes, oxidant and antioxidant defence in ischemia/reperfusion (I/R) injured rat brains. Twenty-one rats were randomly divided into three equal groups: sham-control, ischemia/reperfusion (I/R) and I/R+CAPE. Rats in sham-control group underwent only surgical intervention without bilateral common carotid artery occlusion. Ischemia/reperfusion was induced by bilateral common carotid artery occlusion with atraumatic clips for 30 min, followed by artery reopening. The I/R+CAPE group was subjected to the same surgical procedure as I/R group, but CAPE was administered intraperitoneally at the dose of 15 mu mol kg(-1) twice, 1 h before occlusion and at 12th h of reperfusion. The rats were sacrificed 24 h after I/R. The cAMP concentration was analyzed by ELISA and PDE4 isozyme mRNA transcriptions were evaluated by qRT-PCR methodology in the brain cortex. Ischemia-induced NO production was significantly attenuated by CAPE in the cerebral cortex. CAPE significantly enhanced GSH-Px activity, while SOD, CAT and XO activities non-significantly changed, as compared to the I/R group. CAPE significantly decreased PDE4A and PDE4B transcripts, without changing cAMP levels compared to I/R group. Ischemia-induced neurologic deficit scores were reduced by CAPE. These results suggest that CAPE slightly modulates the antioxidant defense system and NO release in rat brain during global cerebral ischemia/reperfusion injury. In addition, CAPE treatments produce the neuroprotective effect by reducing the levels of some PDE4 transcriptions.en_US
dc.identifier.doi10.9775/kvfd.2014.11228
dc.identifier.endpage884en_US
dc.identifier.issn1300-6045
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84907446954en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage877en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2014.11228
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8524
dc.identifier.volume20en_US
dc.identifier.wosWOS:000344690200009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCAPEen_US
dc.subjectBrainen_US
dc.subjectIschemia/reperfusionen_US
dc.subjectAntioxidant activityen_US
dc.subjectcAMP-phosphodiesterase 4en_US
dc.subjectNeuroprotective effecten_US
dc.subjectRaten_US
dc.titleThe Neuroprotective Effect of Caffeic Acid Phenethyl Ester on Global Ischemia-Reperfusion Injury in Rat Brainsen_US
dc.typeArticleen_US

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