The effect of multiple-dose ivermectin treatment on CD4+/CD8+and the oxidative stress index in goats with udder viral papillomatosis

Basit Öğe Kaydı
dc.authoridKaya, Feyyaz/0000-0001-8820-1509
dc.authoridAYOZGER, LEYLA ELIF OZGU/0000-0003-3320-1688
dc.authoridBozkurt, Gokhan/0000-0003-1837-4492
dc.contributor.authorBozkurt, Gokhan
dc.contributor.authorKaya, Feyyaz
dc.contributor.authorYildirim, Yakup
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorGungor, Orsan
dc.contributor.authorDogan, Firat
dc.contributor.authorAyozger, Leyla Elif Ozgu
dc.date.accessioned2024-09-18T20:06:27Z
dc.date.available2024-09-18T20:06:27Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aims to reveal the therapeutic effect of ivermectin against Capra hircus papillomavirus (ChPV-1) infection and on the CD4+/CD8+ (cluster of differentiation) and oxidative stress index (OSI). Twenty hair goats naturally infected with ChPV-1 were divided into two groups with equal numbers as the ivermectin group and the control groups. Ivermectin was administered subcutaneously at a dose of 0.2 mg/kg to the goats in the ivermectin group on days 0, 7, and 21. Blood samples were collected from the vena jugularis on days 0, 21, 45, and 90. The cluster of differentiation4+/CD8+ ratio was significantly higher in the ivermectin group than in the control group on the 90th day. Furthermore, the CD8+ concentration was significantly decreased in the iver-mectin group on the 90th day compared with the control group. Both total oxidant status (TOS) and OSI were found to be significantly higher in the control group on the 21st and 45th days than in the ivermectin group. On the 90th day, it was determined that the lesions in the ivermectin group improved significantly compared to those in the control group. Additionally, only in the ivermectin group was there a significant difference between the 90th day and the other days in terms of healing. As a result, it can be suggested that ivermectin has positive effects on the immune response and that its oxidative actions are of therapeutic value and do not harm the systemic oxidative status, as in untreated goats.en_US
dc.identifier.doi10.1016/j.rvsc.2023.02.006
dc.identifier.endpage25en_US
dc.identifier.issn0034-5288
dc.identifier.issn1532-2661
dc.identifier.pmid36848794en_US
dc.identifier.scopus2-s2.0-85148851083en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1016/j.rvsc.2023.02.006
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8532
dc.identifier.volume157en_US
dc.identifier.wosWOS:000949458700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofResearch in Veterinary Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCapra hircus papillomavirusen_US
dc.subjectImmune responseen_US
dc.subjectIvermectinen_US
dc.subjectmammaryen_US
dc.subjectPCRen_US
dc.titleThe effect of multiple-dose ivermectin treatment on CD4+/CD8+and the oxidative stress index in goats with udder viral papillomatosisen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full text
Boyut:
4.38 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu