Intravenous ketamine and local bupivacaine infiltration are effective as part of a multimodal regime for reducing post-tonsillectomy pain

dc.contributor.authorInanoglu, Kerem
dc.contributor.authorAkkurt, B. Cagla Ozbakis
dc.contributor.authorTurhanoglu, Selim
dc.contributor.authorOkuyucu, Semsettin
dc.contributor.authorAkoglu, Ertap
dc.date.accessioned2024-09-18T20:08:18Z
dc.date.available2024-09-18T20:08:18Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the effects of a multimodal analgesic regimen, including intravenous ketamine and peritonsillar infiltration of bupivacaine, on post-tonsillectomy pain in children. Material/Methods: Ninety children aged 2-12 years, undergoing tonsillectomy, were enrolled in this randomized, controlled and double-blinded study. Group I (n=30) received intravenous and peritonsillar saline, group II (n=30) received intravenous saline and peritonsillar bupivacaine, and group III (n=30) received intravenous 0.5 mg/kg ketamine and peritonsillar 0.25% bupivacaine (3-5 ml per tonsil). Pain was evaluated using a modified Children's Hospital of Eastern Ontario Pain Scale (mCHEOPS) recorded 15 min and 1, 4, 12, 16, and 24 h postoperatively. Results: No difference was found in the demographic data among the groups. Group I patients who received intravenous and peritonsillar saline solution as placebo had higher pain scores at 15(th) min, and Ist and 4(th) h than group II, and at all time intervals, than group III (P<0.05). Patients in group III also had significantly lower pain scores than group II at all time intervals except at 15(th) min (P<0.05). Analgesic requirements and the time to first analgesia were also significantly (P<0.05) better in the ketamine group. Conclusions: Intravenous ketamine and peritonsillar infiltration with bupivacaine are safe and effective as part of a multimodal regime in reducing post-tonsillectomy pain.en_US
dc.identifier.endpageCR543en_US
dc.identifier.issn1643-3750
dc.identifier.issue10en_US
dc.identifier.pmid19789514en_US
dc.identifier.scopus2-s2.0-70349972805en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageCR539en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8763
dc.identifier.volume15en_US
dc.identifier.wosWOS:000272605000012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildrenen_US
dc.subjecttonsillectomyen_US
dc.subjectpainen_US
dc.subjectketamineen_US
dc.subjectbupivacaineen_US
dc.titleIntravenous ketamine and local bupivacaine infiltration are effective as part of a multimodal regime for reducing post-tonsillectomy painen_US
dc.typeArticleen_US

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