Serum levels of nitric oxide and malondialdehyde in patients with brucellosis

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dc.authorscopusid6701786049
dc.authorscopusid8927152600
dc.authorscopusid6507829293
dc.authorscopusid35584166600
dc.authorscopusid7005923356
dc.contributor.authorSavaş, Lütfü
dc.contributor.authorÖnlen, Yusuf
dc.contributor.authorSavaş, Nazan
dc.contributor.authorPolat, Gürbüz
dc.contributor.authorAslan, Gönül
dc.date.accessioned2024-09-19T15:45:22Z
dc.date.available2024-09-19T15:45:22Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to determine serum levels of nitric oxide (NO) and malondialdehyde (MDA) in patients with brucellosis and to compare these levels with laboratory tests such as erythrocyte sedimentation rate (ESR), aspartate aminotransferase (AST), alanine aminotransterase (ALT), brucella serum agglutination test (SAT), as well as clinical findings such as fever, sweating, and arthricular pain for the diagnosis of brucellosis. Material and Methods: In this study, serum NO and MDA levels were determined in 39 patients with brucellosis before treatment, and in 20 healthy individuals as a control group. Nitrate levels were measured by Green's method, and Yagi's method was used to determine MDA levels. Results: Serum NO and MDA levels were significantly raised in patients with brucellosis when compared to those of the control group (p< 0.05). There was no relation between serum levels of NO, SAT, AST, ALT, or fever, sweat, and arthricular pain. Contrarily, the ESR was also high in patients with high levels of NO (p< 0.05). In addition, there was no relation between MDA and ESR, ALT, SAT, fever, and arthricular pain (p> 0.05); however, in patients with AST levels higher than 40 IU/L, levels of MDA were low (p< 0.05). Furthermore, MDA levels were high in patients with a history of sweating (p< 0.05). Conclusion: Further studies are needed in order to determine whether high levels of NO and MDA in patients with brucellosis are clinically significant. Copyright © 2005 by Türkiye Klinikleri.en_US
dc.identifier.endpage482en_US
dc.identifier.issn1300-0292
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-24744455019en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage478en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14627
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrucellosisen_US
dc.subjectMalondialdehydeen_US
dc.titleSerum levels of nitric oxide and malondialdehyde in patients with brucellosisen_US
dc.title.alternativeBruselloz hastalarinda serum nitrik oksit ve malondialdehit düzeylerien_US
dc.typeArticleen_US

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