Elevated nucleosome level and oxidative stress in schizophrenia patients

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dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorBahceci, B.
dc.contributor.authorKokacya, M. H.
dc.contributor.authorCopoglu, U. S.
dc.contributor.authorBahceci, I
dc.contributor.authorSahin, K.
dc.contributor.authorBagciogiu, E.
dc.contributor.authorDokuyucu, Recep
dc.date.accessioned2024-09-18T20:52:48Z
dc.date.available2024-09-18T20:52:48Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAIM: The aim of this study was to investigate the effect of oxidative stress on nucleosome levels and its relation with the clinical features in schizophrenia patients. MATERIAL AND METHOD: Thirty schizophrenia patients and 30 healthy controls were enrolled in this study. Patients were diagnosed with schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). The control group consisted of 30 healthy subjects matched to the patients with regard to age and gender and who had no history of any psychiatric disorder. The severity of schizophrenia symptoms in the patients was evaluated using the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression Severity Scale (CGI-S). Physical and neurological examinations were performed in each of the patients and controls. RESULTS: Nucleosome, total oxidant levels and OSI values were higher in schizophrenia patients than in controls (p < 0.05). There was no significant difference in the total antioxidant levels. There was a positive correlation between the nucleosome level and PANSS positive subscale (p = 0.028, r = 0.402). There was a positive correlation between TAS and age (p = 0.025, r = 0.289), PANSS total (p < 0.001, r = 0.604). There was a negative correlation between OSI and PANSS total (p = 0.019, r = 0.427), PANSS positive subscale (p = 0.043, r = 0.372). There was a negative correlation between TOS and PANS total (p = 0.028, r = 0.402). CONCLUSION: In this study we found a correlation between nucleosome level and PANSS positive subscale. To our knowledge, this is the first study that evaluates oxidative stress and nucleosomes released from apoptotic cells together (Tab. 2, Ref. 50).en_US
dc.identifier.doi10.4149/BLL_2015_114
dc.identifier.endpage590en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue10en_US
dc.identifier.pmid26531868en_US
dc.identifier.scopus2-s2.0-84973380303en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage587en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_114
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11413
dc.identifier.volume116en_US
dc.identifier.wosWOS:000364353400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectnuclesomeen_US
dc.subjectschizophreniaen_US
dc.subjectoxidative stressen_US
dc.titleElevated nucleosome level and oxidative stress in schizophrenia patientsen_US
dc.typeArticleen_US

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