Ceftriaxone ameliorates cyclosporine A-induced oxidative nephrotoxicity in rat

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dc.authoridNAZIROGLU, Mustafa/0000-0003-0887-6974
dc.authorid, ahmet/0000-0001-6274-5700
dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorIlhan, Selcuk
dc.contributor.authorNaziroglu, Mustafa
dc.contributor.authorOktar, Suleyman
dc.contributor.authorNacar, Ahmet
dc.contributor.authorArica, Vefik
dc.contributor.authorTutanc, Murat
dc.date.accessioned2024-09-18T20:08:08Z
dc.date.available2024-09-18T20:08:08Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractA growing body of evidence now suggested that cyclosporine A (CycA)-induced nephrotoxicity is a crucial clinical problem and oxidative stress is importantly responsible for its toxicity. Ceftriaxone induced antioxidant effect in brain and neuronal tissues against oxidative damage although its antioxidant potential effect on kidney has not been clarified. The aim of this study was to evaluate whether ceftriaxone protects CycA-induced oxidative stress kidney injury in rats. Twenty-four rats were equally divided into four groups. First group was used as control. Ceftriaxone (200 mg/kg) and CycA (15 mg/kg) were administrated to second and third groups for 10 days, respectively. The ceftriaxone and CycA combination was given to rats constituting the fourth group for 10 days. Lipid peroxidation (LP), urea nitrogen and lactate dehydrogenase (LDH) levels were higher in CycA group than in control and ceftriaxone groups although LP, urea nitrogen and LDH levels were lower in ceftriaxone + CycA group than in control and ceftriaxone groups. Glutathione peroxidase and catalase activities were lower in CycA group than in control whereas their activities were increased in control and ceftriaxone groups. Superoxide dismutase activity did not change by the treatments. Ceftriaxone administration recovered also CycA-induced atrophy, vacuolization and exfoliations of tubular epithelium and glomerular collapse in histopathological evaluation of kidney. In conclusion, we observed that ceftriaxone is beneficial on CycA-induced oxidative stress in kidney of rats by modulating oxidative and antioxidant system. Copyright (C) 2011 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1727
dc.identifier.endpage107en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue2en_US
dc.identifier.pmid21287576en_US
dc.identifier.scopus2-s2.0-79952226945en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage102en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1727
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8659
dc.identifier.volume29en_US
dc.identifier.wosWOS:000288079400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectceftriaxoneen_US
dc.subjectcyclosporine Aen_US
dc.subjectnephrotoxicityen_US
dc.subjectoxidative stressen_US
dc.subjectglutathione peroxidaseen_US
dc.subjecthistologyen_US
dc.subjectkidneyen_US
dc.titleCeftriaxone ameliorates cyclosporine A-induced oxidative nephrotoxicity in raten_US
dc.typeArticleen_US

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