Detection of primary clarithromycin resistance of Helicobacter pylori and association between cagA+ status and clinical outcome

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dc.authoridNagiyev, Togrul/0000-0002-5719-370X
dc.contributor.authorYula, Erkan
dc.contributor.authorNagiyev, Togrul
dc.contributor.authorKaya, Ozlem Aycan
dc.contributor.authorInci, Melek
dc.contributor.authorCelik, M. Murat
dc.contributor.authorKoksal, Fatih
dc.date.accessioned2024-09-18T21:02:59Z
dc.date.available2024-09-18T21:02:59Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractHelicobacter pylori was examined in 110 patients (82 (74.5) with gastritis, 18 (16.4) with duodenitis, six (5.5) with duodenal ulcer and gastroesophageal reflux, and four (3.6 %) with normal) with gastrointestinal problems living in rural area, no history of macrolide use, and detected by culture (71.8) or direct detection from gastric biopsies by PCR (82.7 %). Also, cagA gene was identified using PCR and was found positive in 68/91 (74.7 %) strains. The prevalence of clarithromycin-resistant H. pylori was investigated by two methods including PCR-RFLP (7.7 (A2142G 1.1 and A2143G 6.6 %)) and twofold agar dilution (8.9 %) to detect phenotypic and genotypic status simultaneously. Among all the H. pylori positive patients, eight (8.8 %) isolates were found to be resistant to clarithromycin by at least one of the AD and/or PCR-RFLP methods. H. pylori positive rates were significantly correlated with patients' sex, age, and endoscopic findings (p = 0.040, < 0.001 and < 0.001, respectively). There were no differences in gender or endoscopic findings related to cagA (+) and cagA (-) patients. The gene of cagA was not significantly helpful in predicting the clinical outcome of H. pylori infection alone. In conclusion, we revealed that there was a low prevalence of primer clarithromycin resistance in patients living in rural area with no history of macrolide use. The prevalence of mutant strains among the macrolide-resistant H. pylori varies even geographically between close provinces.en_US
dc.identifier.doi10.1007/s12223-012-0192-8
dc.identifier.endpage146en_US
dc.identifier.issn0015-5632
dc.identifier.issue2en_US
dc.identifier.pmid22956464en_US
dc.identifier.scopus2-s2.0-84873523133en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.1007/s12223-012-0192-8
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13188
dc.identifier.volume58en_US
dc.identifier.wosWOS:000314409400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofFolia Microbiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject23s Ribosomal-Rnaen_US
dc.subjectAntibiotic-Resistanceen_US
dc.subjectBiopsy Specimensen_US
dc.subjectTurkish Patientsen_US
dc.subjectBaba2 Genotypesen_US
dc.subjectGastric-Canceren_US
dc.subjectPrevalenceen_US
dc.subjectTurkeyen_US
dc.subjectIceaen_US
dc.subjectVacaen_US
dc.titleDetection of primary clarithromycin resistance of Helicobacter pylori and association between cagA+ status and clinical outcomeen_US
dc.typeArticleen_US

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