Tear film tests in Parkinson's disease patients

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dc.authoridDUMAN, Taskin/0000-0002-6552-4193
dc.contributor.authorTamer, C
dc.contributor.authorMelek, IM
dc.contributor.authorDuman, T
dc.contributor.authorÖksüz, H
dc.date.accessioned2024-09-18T21:03:08Z
dc.date.available2024-09-18T21:03:08Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Parkinson's disease (PD) has both motor and nonmotor features. Parkinson's disease patients are prone to dry eye due to both autonomic dysfunction and motor symptoms affecting blinking. This study was conducted to investigate the changes in tear functions in PD patients. Design: Nonrandomized, prospective, clinical study. Participants: Fifty-six eyes of 56 consecutive patients with PD were studied. Thirty-six eyes of age-matched non-PD patients without pathology affecting tear tests were examined as control subjects. Intervention: Modified Hoehn-Yahr (H-Y) scale, blink rate (BR), and tear tests were examined. Main Outcome Measures: Modified H-Y scale, BR, dry eye assessment questionnaire, meibomian gland evaluation, tear meniscus height, tear breakup time, fluorescein stain, rose bengal stain, Schirmer's test, and phenol red thread test. Results: Overall tear function abnormalities were significantly more common in PD patients (P = 0.001, Mann-Whitney U test). Each test was found to be significantly disturbed in PD patients relative to controls (P<0.05, Mann-Whitney U test). Each PD patient had at least 1 abnormal test. Overall tear function abnormalities as assessed by the total abnormal test count correlated with the H-Y score (P<0.001, Spearman p correlation). Parkinson's disease patients' mean BR (12.7 +/- 7.42 per minute) was significantly less than the controls' (21.8 +/- 7.37) (P<0.01, Student's t test). The abnormality in each tear test, except those for meibomian gland function and tear meniscus height, was significantly related to the H-Y scores (P<0.05, chi(2) linear-by-linear association). Conclusion: The results of this study indicate that PD is associated with disturbances in tear function. With the exception of meibomian gland disease and tear meniscus height, the tests were found to have a linear association with the H-Y scale, which may be attributed to associated dysfunctions of PD. (c) 2005 by the American Academy of Ophthalmology.en_US
dc.identifier.doi10.1016/j.ophtha.2005.04.025
dc.identifier.endpage1800en_US
dc.identifier.issn0161-6420
dc.identifier.issue10en_US
dc.identifier.pmid16095705en_US
dc.identifier.scopus2-s2.0-25844449228en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1795en_US
dc.identifier.urihttps://doi.org/10.1016/j.ophtha.2005.04.025
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13270
dc.identifier.volume112en_US
dc.identifier.wosWOS:000232299200022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofOphthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMeibomian Gland Dysfunctionen_US
dc.subjectEvaporative Dry Eyeen_US
dc.subjectBreak-Up Timeen_US
dc.subjectSchirmer Testen_US
dc.subjectAutonomic Dysfunctionen_US
dc.subjectLacrimationen_US
dc.subjectDeficiencyen_US
dc.subjectMeniscusen_US
dc.subjectHeighten_US
dc.titleTear film tests in Parkinson's disease patientsen_US
dc.typeArticleen_US

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