45S5 Bioactive Glass-Ointment Positively Effects on Wound Healing in Rats by Regulating TNF?, Il-10, VEGF, and TGF?

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dc.authoridKIRGIZ, Omer/0000-0002-0222-1363
dc.contributor.authorKirgiz, Omer
dc.contributor.authorAltug, Muhammed Enes
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorHan, Mehmet Cengiz
dc.contributor.authorAkcakavak, Goekhan
dc.contributor.authorOzarslan, Ali Can
dc.contributor.authorYucel, Sevil
dc.date.accessioned2024-09-18T20:04:25Z
dc.date.available2024-09-18T20:04:25Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAimThis study aimed to investigate the effects of 45S5 bioactive glass-ointment (BG) on cutaneous wound healing in rats at the molecular, biochemical, and histopathological levels.Materials and MethodsThirty-two rats were divided into four groups (n = 8): Control, Sham, BG, and DEX (Dexpanthenol). While no wound treatment was applied to the CONTROL, a wound model was created in the Sham, and no treatment was applied. A wound model was created for other groups, and BG and DEX were applied locally for 21 days. During the 21-day experiment period, feed and water consumption and weight changes were observed. Wound areas were calculated on days 0, 3, 7, 4, and 21. Following treatment, the rats were euthanized and tissues from the wound area and blood samples were collected. While the expression levels of tumor necrosis factor-alpha (TNF alpha), Interleukin 6 (IL6), Interleukin 10 (IL10), transforming growth factor-beta (TGF beta), and vascular endothelial growth factor (VEGF) genes were determined by qPCR, the levels of TNF alpha, IL6, and IL10 proteins were measured by ELISA.ResultsIt was observed that the BG group showed anti-inflammatory activity by suppressing TNF alpha levels and stimulating IL-10. In addition, it was determined that BG increased fibroblast activity and vascularization.ConclusionCurrent findings showed that topical application of BG has anti-inflammatory effects, while also accelerating healing by increasing vascularity and making positive contributions to tissue healing. This study investigates the effects of topical application of 45S5 bioactive glass-ointment (BG) on wound healing in rats at the molecular and histopathological levels. The findings demonstrate that BG exhibits anti-inflammatory activity, enhances vascularization, accelerates healing, and contributes positively to tissue repair.imageen_US
dc.description.sponsorshipHatay Mustafa Kemal University [20.D.003]en_US
dc.description.sponsorshipThis study was supported by Hatay Mustafa Kemal University (Project No. 20.D.003).en_US
dc.identifier.doi10.1002/jcla.25094
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.pmid39235180en_US
dc.identifier.scopus2-s2.0-85203070869en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.25094
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8160
dc.identifier.wosWOS:001304611000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbioactive glassesen_US
dc.subjectELISAen_US
dc.subjectgene expressionen_US
dc.subjecthistopathologyen_US
dc.subjectwound healingen_US
dc.title45S5 Bioactive Glass-Ointment Positively Effects on Wound Healing in Rats by Regulating TNF?, Il-10, VEGF, and TGF?en_US
dc.typeArticleen_US

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