Oxidative stress in chronic otitis media

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dc.authoridKanlikama, Muzaffer/0000-0002-3537-7778
dc.authoridBaysal, Elif/0000-0001-9414-9401
dc.contributor.authorBaysal, Elif
dc.contributor.authorAksoy, Nurten
dc.contributor.authorKara, Ferit
dc.contributor.authorTaysi, Seyithan
dc.contributor.authorTaskin, Abdullah
dc.contributor.authorBilinc, Hasan
dc.contributor.authorCevik, Cengiz
dc.date.accessioned2024-09-18T20:08:27Z
dc.date.available2024-09-18T20:08:27Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractChronic otitis media usually presents with a benign tumor-like lesion of the temporal bone known as a cholesteatoma. The role of oxidative stress in the pathogenesis of chronic otitis media and cholesteatoma has not yet been fully explored. Therefore, the aim of this study was to investigate the oxidative stress markers and antioxidant enzymes in patients with cholesteatomatous and noncholesteatomatous chronic otitis media and in healthy subjects. A prospective controlled trial was performed on cholesteatomatous and noncholesteatomatous chronic otitis media patients in a tertiary referral center in a university hospital. A total of 75 subjects, including 25 cholesteatomatous and 25 noncholesteatomatous chronic otitis media patients and 25 healthy subjects participated in this study. Serum total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly increased in the patient groups with or without cholesteatoma compared with the control group. Serum total antioxidant status (TAS) levels and Paraoxonase and arylesterase activity were significantly lower in the patient groups with or without cholesteatoma compared with the control group. Serum TOS and OSI levels were lower in the noncholesteatomatous group, whereas serum TAS levels were higher compared with the cholesteatomatous group. Serum arylesterase activity was significantly lower in the noncholesteatomatous group compared with the control group. The results of this study reveal that in cholesteatoma cases, the oxidative stress and antioxidant enzyme imbalance were more significant than in cases of chronic otitis media without cholesteatoma.en_US
dc.identifier.doi10.1007/s00405-012-2070-z
dc.identifier.endpage1208en_US
dc.identifier.issn0937-4477
dc.identifier.issue4en_US
dc.identifier.pmid22711004en_US
dc.identifier.startpage1203en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-012-2070-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8835
dc.identifier.volume270en_US
dc.identifier.wosWOS:000316818000004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic otitis mediaen_US
dc.subjectCholesteatomaen_US
dc.subjectOxidative stressen_US
dc.subjectParaoxonaseen_US
dc.subjectProlidaseen_US
dc.titleOxidative stress in chronic otitis mediaen_US
dc.typeArticleen_US

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