Preparation and characterization of papaverine-loaded poly[(R)-3- hydroxybutyrate] membranes to be used in the prevention of vasospasm

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dc.authorscopusid36172887100
dc.authorscopusid56243100300
dc.authorscopusid24334063400
dc.authorscopusid36617322600
dc.authorscopusid6701662131
dc.contributor.authorGüven, Eylem
dc.contributor.authorGüven, Eşref O?uz
dc.contributor.authorBayram, Cem
dc.contributor.authorKazak, Osman Nuri
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned2024-09-19T15:43:49Z
dc.date.available2024-09-19T15:43:49Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe objective of this study is the preparation and characterization of poly[(R)-3-hydroxybutyrate] (PHB) membrane loaded with a vasodialative agent (i.e., papaverine hydrochloride) as a blood vessel coverage strip to be used in the prevention of undesired vascular vasospasm. Papaverine-loaded PHB membranes were especially designed to act locally and provide an efficient, long term, and sustained prevention of vasospasm at the site of the newly created vascular anastomosis without any systemic vasodilation effect of the papaverine, which may be life-threatening for the patient. The membranes were prepared by gelation of PHB followed by solvent casting. PHB membranes were characterized in terms of morphology, chemical structure, swelling behavior, in vitro drug release, degradation, and blood compatibility studies as in vitro coagulation tests. Activated partial thromboplastin time, prothrombin time, and fibrinogen concentration were measured by blood coagulation assays. Investigated and evaluated parameters for in vitro drug release, degradation, and in vitro coagulation studies were the concentration of PHB and drug content. Similar effective parameters were used for swelling behavior studies (i.e., concentration of PHB and drug content). Drug release, swelling behavior, degradation, and in vitro coagulation of the membranes were found to be influenced by these parameters. Obtained results showed that papaverine-loaded PHB membranes provide an efficient and advantegous means for the prevention of vasospasm during vascular anastomosis as a local application. ©PDA, Inc. 2010.en_US
dc.identifier.endpage326en_US
dc.identifier.issn1079-7440
dc.identifier.issue4en_US
dc.identifier.pmid21502032en_US
dc.identifier.scopus2-s2.0-78149324445en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage316en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14580
dc.identifier.volume64en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofPDA Journal of Pharmaceutical Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood compatibilityen_US
dc.subjectCoagulationen_US
dc.subjectDegradationen_US
dc.subjectPapaverine hydrochlorideen_US
dc.subjectPolyhydroxybutyrate membraneen_US
dc.subjectVasospasmen_US
dc.titlePreparation and characterization of papaverine-loaded poly[(R)-3- hydroxybutyrate] membranes to be used in the prevention of vasospasmen_US
dc.typeArticleen_US

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