Predictors of Mortality and Functional Outcome in Pregnancy and Puerperium-Related Cerebral Venous Thrombosis

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dc.authoridWASAY, MOHAMMAD/0000-0003-3750-2613
dc.authoridCano Nigenda, Vanessa/0000-0002-8544-9717
dc.authoridBarboza, Miguel A./0000-0002-1037-962X
dc.contributor.authorKhan, Maria
dc.contributor.authorArauz, Antonio
dc.contributor.authorUluduz, Derya
dc.contributor.authorBarboza, Miguel A.
dc.contributor.authorDuman, Taskin
dc.contributor.authorCano-Ningenda, Vanessa
dc.contributor.authorAwan, Safia
dc.date.accessioned2024-09-18T20:08:11Z
dc.date.available2024-09-18T20:08:11Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Cerebral venous thrombosis (CVT) associated with pregnancy and puerperium has long been recognized, with poor information in terms of functional outcomes. Our objective was to analyze risk factors, clinical, imaging, and laboratory variables to predict functional outcome and death in this population. Methods: CVT registries from three referral centers from Pakistan, Turkey, and Mexico, recruiting prospective cases, were combined for CVT associated with pregnancy or puerperium. Datasets and variables were standardized. Demographic characteristics, presentation, risk factors, and functional outcomes in pregnancy/puerperium-related CVT were analyzed. Binary logistic regression was used to assess predictors of outcome. The main outcome was modified Rankin score >2 at 30 days and mortality at 30 days. Results: Five hundred fifty-three cases (median age 28 years [IQR 23-34]) of CVT associated with pregnancy and puerperium were included; 439 cases (79.4%) happened in the puerperium and 20.6% during pregnancy (53.5% occurred during the first trimester). Anemia (36.7%) and dehydration (22.9%) were the commonest obstetric risk factors identified. Predictors of poor outcome (mRS >2) were encephalopathy (OR 12.8, p < 0.001), cases from Mexican origin (OR 3.1, p = 0.004), fever/puerperal infection (OR 2.7, p = 0.02), and anemia (OR 2.2, p = 0.01). Cases from Mexican origin (OR 12.0, p = 0.003) and Encephalopathy (OR 7.7, p < 0.001), presented with the highest mortality association in the final adjusted model. Discussion/Conclusion: In CVT associated with pregnancy and puerperium, encephalopathy, fever/puerperal infection, and anemia are associated with bad functional outcomes, meanwhile encephalopathy and cases from Mexican origin with higher mortality in the acute (30-days) of CVT onset. Anemia and infection are potential reversible predictors of poor outcome that clinicians should be aware of in order to prevent poor outcomes in these patients.en_US
dc.identifier.doi10.1159/000527155
dc.identifier.endpage400en_US
dc.identifier.issn1015-9770
dc.identifier.issn1421-9786
dc.identifier.issue4en_US
dc.identifier.pmid36566747en_US
dc.identifier.scopus2-s2.0-85169710759en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.1159/000527155
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8688
dc.identifier.volume52en_US
dc.identifier.wosWOS:000904806200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofCerebrovascular Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCerebral venous thrombosisen_US
dc.subjectStrokeen_US
dc.subjectPregnancyen_US
dc.subjectPuerperiumen_US
dc.subjectWomenen_US
dc.titlePredictors of Mortality and Functional Outcome in Pregnancy and Puerperium-Related Cerebral Venous Thrombosisen_US
dc.typeArticleen_US

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