Optical coherence tomography changes in ankylosing spondylitis patients on long-term adalimumab treatment

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dc.authoridKULAKLI, SEVGI/0000-0001-7886-1060
dc.authoridSARI, ILKER FATIH/0000-0003-0127-6503
dc.authoridOZER, MURAT ATABEY/0000-0003-1807-6911
dc.contributor.authorYavuz, Nurce Cilesizoglu
dc.contributor.authorOzer, Murat Atabey
dc.contributor.authorSari, Ilker Fatih
dc.contributor.authorKulakli, Sevgi
dc.contributor.authorTatli, Samet
dc.contributor.authorOgut, Halil
dc.date.accessioned2024-09-18T21:00:25Z
dc.date.available2024-09-18T21:00:25Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: Long-term ocular effects of tumor necrosis factor-alpha inhibitors remain to be elucidated. This study aimed to examine the long-term effects of adalimumab use on neural tissue of the anterior visual pathways using optical coherence tomography in patients with ankylosing spondylitis.METHODS: This was a single-center, open-label, cross-sectional study conducted at the Giresun University Faculty of Medicine, Physical Medicine and Rehabilitation Department, between November 2019 and August 2020. This study included 26 ankylosing spondylitis patients receiving adalimumab for at least 1 year and 21 healthy controls. All subjects underwent a full ophthalmological examination and optical coherence tomography examination with the following measurements: peripapillary retinal nerve fiber layer thickness, peripapillary retinal thickness, peripapillary choroidal thickness, ganglion cell complex thickness, and the optic head properties.RESULTS: Peripapillary retinal nerve fiber layer thickness and retinal thickness measurements were lower in the adalimumab group. In addition, ganglion cell complex thickness was significantly lower and the cup-to-disc ratio was significantly higher in the adalimumab group (p<0.05). However, the two groups did not differ in terms of peripapillary choroidal thickness and disc area (p>0.05).CONCLUSION: Although tumor necrosis factor-alpha inhibitors have some favorable effects on the ocular involvement of patients with ankylosing spondylitis, they may also have paradoxical detrimental effects as evidenced by structural changes observed by optical coherence tomography. Future studies with better design, probably including a large number of patients with a range of rheumatological diseases and tumor necrosis factor-alpha inhibitors, are warranted.en_US
dc.identifier.doi10.1590/1806-9282.20220052
dc.identifier.endpage1630en_US
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue12en_US
dc.identifier.pmid36449785en_US
dc.identifier.scopus2-s2.0-85144592257en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1626en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20220052
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12667
dc.identifier.volume68en_US
dc.identifier.wosWOS:000904384200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTumor necrosis factor alphaen_US
dc.subjectAdalimumaben_US
dc.subjectOptical coherence tomographyen_US
dc.titleOptical coherence tomography changes in ankylosing spondylitis patients on long-term adalimumab treatmenten_US
dc.typeArticleen_US

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