Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice

Basit Öğe Kaydı
dc.authoridYaman, Mehmet/0000-0002-3008-2671
dc.authoridKISACAM, Mehmet Ali/0000-0003-0521-9434
dc.contributor.authorKisacam, Mehmet Ali
dc.contributor.authorKocamuftuoglu, Gonca Ozan
dc.contributor.authorOzan, Ibrahim Enver
dc.contributor.authorYaman, Mehmet
dc.contributor.authorOzan, Sema Temizer
dc.date.accessioned2024-09-18T20:57:04Z
dc.date.available2024-09-18T20:57:04Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTumor microenvironment, genetic, and non-genetic factors are responsible for the atypical metabolic feature of cancer cells. Aberrant activity of PI3K/Akt pathway, increased glycolytic flux, and decreased intracellular pH gradient are the leading causes of this feature. Calcium Fructoborate (CaFB), a sugar-borate ester, has major benefits for human health. The aim of this study was to explore the implication of CaFB on experimentally induced skin cancer in vivo. According to the treatment, 92 female Balb-c mice are divided into six groups: control, CaFB (3 mg/kg/day), 7,12-Dimethylbenz(a)anthracene (DMBA)+12-O-tetradecanoylphorbol-13-acetate (TPA) (97.5 nmol DMBA, 6.5 nmol TPA), T1: CaFB+DMBA+TPA (3 mg/kg/day CaFB together with DMBA), T2: DMBA+CaFB+TPA (3 mg/kg/day CaFB together with TPA), T3: DMBA+TPA+CaFB (3 mg/kg/day CaFB after tumor formation). Topical DMBA and TPA application resulted in a significant increase in the protein levels, immunoreactivity, and mRNA expression of HRAS, HIF1 alpha, Akt, and PTEN (p< 0.05). Moreover, an increase in the number of TUNEL-positive cells was observed in DMBA-TPA group compared with the control group (p< 0.05). CaFB application reduced the protein levels, immunoreactivity, and mRNA expressions of HRAS, HIF1 alpha, Akt, and PTEN and also decreased the number of TUNEL-positive cells. Recent evidence obtained from our study validated that CaFB treatment may have skin cancer-preventing effect.en_US
dc.description.sponsorshipNational Boron Institution of Turkey [2016-31-07-15-003] Funding Source: Medlineen_US
dc.identifier.doi10.1007/s12011-019-01897-y
dc.identifier.endpage144en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid31529243en_US
dc.identifier.scopus2-s2.0-85073984992en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-019-01897-y
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12272
dc.identifier.volume196en_US
dc.identifier.wosWOS:000540211900015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSkin canceren_US
dc.subjectHRASen_US
dc.subjectAkten_US
dc.subjectCalcium Fructoborateen_US
dc.subjectSkin cancer-preventing effecten_US
dc.titleCalcium Fructoborate Prevents Skin Cancer Development in Balb-c Miceen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
33.88 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu