The predictors of COVID-19 mortality in a nationwide cohort of Turkish patients

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dc.authorid, Zeynep Ture/0000-0001-6895-0318
dc.authoridElbek, Osman/0000-0002-8968-2436
dc.authoridBabayigit, Cenk/0000-0001-9760-6081
dc.authoridAkgun, Metin/0000-0003-3404-4274
dc.authoridFAKILI, FUSUN/0000-0002-1602-5240
dc.authoridbaydar, oya/0000-0001-7320-976X
dc.authoridAltinisik, Goksel/0000-0001-6869-1301
dc.contributor.authorKokturk, Nurdan
dc.contributor.authorBabayigit, Cenk
dc.contributor.authorKul, Seval
dc.contributor.authorCetinkaya, Pelin Duru
dc.contributor.authorNayci, Sibel Atis
dc.contributor.authorBaris, Serap Argun
dc.contributor.authorKarcioglu, Oguz
dc.date.accessioned2024-09-18T20:13:25Z
dc.date.available2024-09-18T20:13:25Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe COVID-19-related death rate varies between countries and is affected by various risk factors. This multi-center registry study was designed to evaluate the mortality rate and the related risk factors in Turkey. We retrospectively evaluated 1500 adults with COVID-19 from 26 centers who were hospitalized between March 11 and July 31, 2020. In the study group, 1041 and 459 cases were diagnosed as definite and highly probable cases, respectively. There were 993 PCR-positive cases (66.2%). Among all cases, 1144 (76.3%) were diagnosed with non-severe pneumonia, whereas 212 (14.1%) had severe pneumonia. Death occurred in 67 patients, corresponding to a mortality rate of 4.5% (95% CI:3.5-5.6). The univariate analysis demonstrated that various factors, including male sex, age >= 65 years and the presence of dyspnea or confusion, malignity, chronic obstructive lung disease, interstitial lung disease, immunosuppressive conditions, severe pneumonia, multiorgan dysfunction, and sepsis, were positively associated with mortality. Favipiravir, hydroxychloroquine and azithromycin were not associated with survival. Following multivariate analysis, male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were found to be independent risk factors for mortality. Among the biomarkers, procalcitonin levels on the 3rd-5th days of admission showed the strongest associations with mortality (OR: 6.18; 1.6-23.93). This study demonstrated that the mortality rate in hospitalized patients in the early phase of the COVID-19 pandemic was a serious threat and that those patients with male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were at increased risk of mortality; therefore, such patients should be closely monitored.en_US
dc.description.sponsorshipTurkish Thoracic Societyen_US
dc.description.sponsorshipThe study partially funded by The Turkish Thoracic Society.en_US
dc.identifier.doi10.1016/j.rmed.2021.106433
dc.identifier.issn0954-6111
dc.identifier.issn1532-3064
dc.identifier.pmid33957434en_US
dc.identifier.scopus2-s2.0-85105086539en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2021.106433
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9180
dc.identifier.volume183en_US
dc.identifier.wosWOS:000654066600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofRespiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19 deathsen_US
dc.subjectIn-hospital mortalityen_US
dc.subjectRisk factorsen_US
dc.titleThe predictors of COVID-19 mortality in a nationwide cohort of Turkish patientsen_US
dc.typeArticleen_US

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