Investigation of C5a receptor gene 450 C/T polymorphism in Turkish patients with familial Mediterranean fever

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dc.contributor.authorErken, Eren
dc.contributor.authorGunesacar, Ramazan
dc.contributor.authorOzer, Huseyin T. E.
dc.date.accessioned2024-09-18T20:20:00Z
dc.date.available2024-09-18T20:20:00Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractFamilial Mediterranean fever (FMF) is a genetic disorder with acute inflammatory serosal attacks due to MEFV gene mutations which resides in chromosome 16. Lack of a C5a inhibitor activity in the peritoneum has previously been proposed in part to contribute in propagation of the serosal inflammation in FMF attacks. The aim of this study is to investigate C5a receptor (C5aR) gene polymorphism in patients with FMF and its relation to the main features of the disease. A polymorphism in the coding region of C5aR gene leading to C to T transition at nucleotide position 450 has been investigated in 85 non-related Turkish FMF patients and 160 non-related healthy controls by using PCR-RFLP. The frequencies of C5aR gene 450 CT genotype and T allele were not significantly different between Turkish FMF patients and healthy subjects (14.12 and 8.24% for FMF vs. 10 and 5% for controls, respectively). C5aR gene 450 CT genotype tended to associate with the presence Henoch-Schonlein purpura (OR: 1.25, 95% CI: 0.917-1.704, P = 0.017) but with no other clinical findings of the disease. C5aR polymorphism might be searched in populations having high prevalence of FMF.en_US
dc.identifier.doi10.1007/s11033-009-9677-1
dc.identifier.endpage276en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue1en_US
dc.identifier.pmid19657723en_US
dc.identifier.scopus2-s2.0-77949270838en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-009-9677-1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10003
dc.identifier.volume37en_US
dc.identifier.wosWOS:000273319000041en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectComplement C5a receptoren_US
dc.subjectPolymorphismen_US
dc.subjectHenoch-Schonlein purpuraen_US
dc.titleInvestigation of C5a receptor gene 450 C/T polymorphism in Turkish patients with familial Mediterranean feveren_US
dc.typeArticleen_US

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