TNM and Modified Dukes staging along with the demographic characteristics of patients with colorectal carcinoma

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dc.contributor.authorAkkoca, Ayse Neslin
dc.contributor.authorYanik, Serdar
dc.contributor.authorOzdemir, Zeynep Tugba
dc.contributor.authorCihan, Fatma Goksin
dc.contributor.authorSayar, Suleyman
dc.contributor.authorCincin, Tarik Gandi
dc.contributor.authorCam, Akin
dc.date.accessioned2024-09-18T20:25:17Z
dc.date.available2024-09-18T20:25:17Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Colon adenocarcinoma, is the most common cancer in gastrointesinal system (GIS). The whole world is an important cause of morbidity and mortality. TNM and modified Dukes classification which has great importance in the diagnosis and treatment of Colorectal cancer (CRC). TNM and Modified Dukes classification results of histopathological examination and the demographic characteristics of patients and their relation were investigated. Materials and methods: Lower gastrointestinal operation results of 85 patients were examined accepted to clinical Pathology between January 1997-November 2013. Colon cancer had been diagnosed at 85 patients with pathology materials and staging was done according to the TNM and Modified Duke classification. The demographic characteristics of patients, differentiation grade, lymph node involvement, serous involvement were evaluated retrospectively. Results: In this study 37 patients (43.52%) were men and 48 (56.47%) were women. Ages of patients were between 19 and 87 with a mean age of 57.31 +/- 15.31. Lymph node, differentiation, serosa involvement, Modified Dukes and TNM classification was assessed according to sex and age. TNM classification by sex was not statistically significant (p > 0.05). There was no statistically significant relationship between age and differentiation (p = 0.085). Value of differentiation increased towards from 1 to 3 inversely proportional to age. So young patients defined as well-differentiated at the conclusion. Negative relationship was evaluated between age and TNM Class variables. As a result, the relationship between age and TNM was not significant (p > 0.05). However, with increasing age the degree of staging was also found to increase. TNM classification was associated with the differentiation and it was significant (p = 0.043). Conclusion: Colon cancer, when contracted at an early stage, it is suitable for surgery and curative treatment can be done with minimal morbidity and mortality. However, some of the patients have advanced disease at diagnosis and their 5-year survival rate is only 8%. Every year there is prolongation of overall survival of colon cancer. It is so common cancer type so that determination of prognostic factors, disease staging and treatment strategy which affects survival is significant.en_US
dc.identifier.endpage2835en_US
dc.identifier.issn1940-5901
dc.identifier.issue9en_US
dc.identifier.pmid25356145en_US
dc.identifier.scopus2-s2.0-84907842152en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2828en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10220
dc.identifier.volume7en_US
dc.identifier.wosWOS:000345121000054en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastrointesinal system (GIS)en_US
dc.subjectcolorectal cancer (CRC)en_US
dc.subjectTNMen_US
dc.subjectModified Dukes stagingen_US
dc.titleTNM and Modified Dukes staging along with the demographic characteristics of patients with colorectal carcinomaen_US
dc.typeArticleen_US

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