Association of left ventricular diastolic function abnormalities with aortic elastic properties in asymptomatic patients with type 2 diabetes mellitus. A tissue doppler echocardiographic study

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dc.contributor.authorSeyfeli, E.
dc.contributor.authorDuru, M.
dc.contributor.authorSaglam, H.
dc.contributor.authorAkgul, F.
dc.contributor.authorKuvandik, G.
dc.contributor.authorKaya, H.
dc.contributor.authorYalcin, F.
dc.date.accessioned2024-09-18T21:05:20Z
dc.date.available2024-09-18T21:05:20Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the association between the aortic elastic properties and the left ventricular diastolic function measured by tissue Doppler echocardiography (TDE) in asymptomatic type 2 diabetes mellitus. Methods: Fifty-seven asymptomatic patients with type 2 diabetes (33 women, mean age: 49 +/- 6 years) and 25 healthy control subjects (19 women, mean age: 46 +/- 7 years) were included in the present study. Diastolic filling indices were measured by conventional (CE) and tissue Doppler echocardiography. The aortic elastic properties [Aortic stiffness index (ASI), aortic distensibility and strain] were measured as previous definition. Results: Compared with control subjects, the ratio of LV diastolic abnormalities measured by CE and TDE were found higher in patients with type 2 diabetes (36% and 73.6%, p = 0.001, respectively, and 52% and 89.4%, p < 0.001, for septal annulus; 48% and 89.4%, p < 0.001 for septal basal respectively). The ASI was significantly higher (p < 0.001), aortic distensibility and aortic strain were also significantly lower in patients with type 2 diabetes than control subjects (p < 0.001 and p < 0.001 respectively). In the regression analysis, Ao distensibility was correlated to age (beta = -0.299, p = 0.004), septal basal Em/Am ratio (beta =0.543, p < 0.001) and HDL-cholesterol (beta = 0.192, p = 0.039). ASI was also correlated only to age (beta = 0.255, p = 0.044), the presence of diabetes mellitus (beta = 0.304, p = 0.009), mitral A wave (beta = 0.322, p = 0.013) and mitral annulus Em wave (beta = -0.505, p < 0.001). Conclusion: The aortic elastic function is impaired in asymptomatic patients with type 2 diabetes. Increased ASI and decreased Ao distensibility are closely associated with diastolic filling indices measured by CE and TDE.en_US
dc.identifier.doi10.1111/j.1742-1241.2007.01381.x
dc.identifier.endpage1365en_US
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue9en_US
dc.identifier.pmid17511794en_US
dc.identifier.scopus2-s2.0-49349085446en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1358en_US
dc.identifier.urihttps://doi.org/10.1111/j.1742-1241.2007.01381.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13520
dc.identifier.volume62en_US
dc.identifier.wosWOS:000258291100012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiovascular Mortalityen_US
dc.subjectArterial Stiffnessen_US
dc.subjectYoung-Patientsen_US
dc.subjectRisk-Factoren_US
dc.subjectDysfunctionen_US
dc.subjectIncreaseen_US
dc.subjectWomenen_US
dc.subjectMenen_US
dc.titleAssociation of left ventricular diastolic function abnormalities with aortic elastic properties in asymptomatic patients with type 2 diabetes mellitus. A tissue doppler echocardiographic studyen_US
dc.typeArticleen_US

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