Investigation of Parvovirus B19 Seroprevalence, Endothelin-1 Synthesis, and Nitric Oxide Levels in the Etiology of Essential Hypertension

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dc.contributor.authorMotor, Vicdan Koksaldi
dc.contributor.authorArica, Secil
dc.contributor.authorMotor, Sedat
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorEvirgen, Omer
dc.contributor.authorInci, Melek
dc.contributor.authorGokce, Cumali
dc.date.accessioned2024-09-18T20:26:52Z
dc.date.available2024-09-18T20:26:52Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and Aims: Many studies have focused on the role of pathogen infection in hypertension (HT). It has been postulated that increased vascular tonus in HT is basically related to the imbalance between vasodilator, such as nitric oxide (NO), and vasoconstrictor, such as endothelin-1 (ET-1), substances secreted by endothelium. The aim of the present study was to investigate the seroprevalence of human parvovirus B19 (HPV B19) in the etiology of essential HT and the effect of HPV B19 on ET-1 and NO levels in this disorder. Materials and Methods: A total of 135 participants were enrolled in the study (90 patient and 45 controls). Antibodies to HPV B19 and ET-1 were measured by enzyme-linked immunosorbent assay method. Nitric oxide levels were calculated according to the Griess reaction. Results: Of the total participants, 27 patients (30%) and 7 control subjects (15.6%) had IgM positive (P = .068), whereas 27 patients (30%) and 14 control subjects (31.1%) had IgG positive (P = .895). There was no statistical difference between patients and control subjects in terms of serum ET-1 and NO levels. Conclusions: The role of HPV B19 in the etiology of essential HT was not shown in the present study. A larger sample may be needed for the investigation of these relations.en_US
dc.identifier.doi10.3109/10641963.2011.628731
dc.identifier.endpage221en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue3en_US
dc.identifier.pmid22468640en_US
dc.identifier.scopus2-s2.0-84859748444en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.3109/10641963.2011.628731
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10571
dc.identifier.volume34en_US
dc.identifier.wosWOS:000302754200009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofClinical and Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthuman parvovirus B19en_US
dc.subjecthypertensionen_US
dc.subjectnitric oxideen_US
dc.subjectendothelin-1en_US
dc.subjectprevalenceen_US
dc.titleInvestigation of Parvovirus B19 Seroprevalence, Endothelin-1 Synthesis, and Nitric Oxide Levels in the Etiology of Essential Hypertensionen_US
dc.typeArticleen_US

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