Assessment of corneal topographic, tomographic, densitometric, and biomechanical properties of Fabry patients with ocular manifestations

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dc.authoridTURGUT, FARUK/0000-0003-1910-7433
dc.authoridTEKIN, KEMAL/0000-0002-7461-6129
dc.contributor.authorCankurtaran, Veysel
dc.contributor.authorTekin, Kemal
dc.contributor.authorCakmak, Ayse Idil
dc.contributor.authorInanc, Merve
dc.contributor.authorTurgut, Faruk Hilmi
dc.date.accessioned2024-09-18T20:04:30Z
dc.date.available2024-09-18T20:04:30Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose To investigate whether cornea verticillata affects corneal topography, tomography, densitometry, or biomechanics of Fabry patients with ocular manifestations and to compare these results with those obtained from healthy subjects. Methods This prospective, cross-sectional study included 23 Fabry patients (Fabry group) with cornea verticillata and the 37 age- and sex-matched healthy subjects (control group). After comprehensive ophthalmological examinations, corneal topography, tomography, and densitometry measurements were taken using Pentacam HR and corneal biomechanics were captured via Corvis ST for all participants. Results All the investigated topographic and tomographic values were similar in the eyes with Fabry disease (FD) and the controls (P > 0.05). The corneal densitometry values of patients with FD were statistically significantly higher in all the concentric zones and layers, except posterior 0-2 mm and posterior 2-6 mm zones, compared to the controls (P < 0.05). The mean values of A1 velocity, A2 velocity, deformation amplitude ratio, Corvis biomechanical index, tomographic and biomechanical index, and Stiffness parameter at the first applanation in the Fabry group were statistically significantly different compared to control group (P < 0.05). However, the mean values of A1 length, A2 length, and the biomechanically corrected intraocular pressure were similar between the groups (P = 0.317, P = 0.819, and P = 0.468; respectively). Conclusion Although cornea verticillata associated with FD is not considered to affect vision, it is associated with increased light backscattering and reduced corneal transparency as well as altered corneal biomechanical properties.en_US
dc.identifier.doi10.1007/s00417-019-04593-8
dc.identifier.endpage1064en_US
dc.identifier.issn0721-832X
dc.identifier.issn1435-702X
dc.identifier.issue5en_US
dc.identifier.pmid31915973en_US
dc.identifier.scopus2-s2.0-85077594916en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1057en_US
dc.identifier.urihttps://doi.org/10.1007/s00417-019-04593-8
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8210
dc.identifier.volume258en_US
dc.identifier.wosWOS:000526829600013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofGraefes Archive For Clinical and Experimental Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomechanicsen_US
dc.subjectCornea verticillataen_US
dc.subjectDensitometryen_US
dc.subjectFabry diseaseen_US
dc.subjectTopographyen_US
dc.titleAssessment of corneal topographic, tomographic, densitometric, and biomechanical properties of Fabry patients with ocular manifestationsen_US
dc.typeArticleen_US

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