Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey

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dc.authoridIzmirli, Muzeyyen/0000-0002-8545-863X
dc.contributor.authorIzmirli, Muzeyyen
dc.contributor.authorSen, Bilge Bulbul
dc.contributor.authorRifaioglu, Eminenur
dc.contributor.authorGogebakan, Bulent
dc.contributor.authorAldemir, Ozgur
dc.contributor.authorSen, Tuba
dc.contributor.authorEkiz, Ozlem
dc.date.accessioned2024-09-18T20:32:50Z
dc.date.available2024-09-18T20:32:50Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR). Objective: In this study, we aimed to investigate methylenetetrahydrofolate C677T polymorphism in psoriasis patients in Turkey. Methods: The study included 96 patients with psoriasis and 77 controls from southern Turkey. Methylenetetrahydrofolate C677T polymorphism was analysed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism methods. Results: In the psoriasis group, 34 CC (35.4%), 46 CT (47.9%) and 16 TT (16.7%) genotypes were found, respectively; while in the control group, the figures were 39 (50.6%), 35 (45.5%), 3 (3.9%). Homozygote and heterozygote T alleles of methylenetetrahydrofolate C677T polymorphism were significantly higher in the psoriasis than in the control group (p=0.013). Conclusion: We firstly found a correlation between methylenetetrahydrofolate C677T polymorphism and psoriasis among the southern Turkish population.en_US
dc.description.sponsorshipMustafa Kemal University Research Fund [BAP:11780]en_US
dc.description.sponsorshipMustafa Kemal University Research Fund (BAP:11780).en_US
dc.identifier.doi10.1590/abd1806-4841.20164766
dc.identifier.endpage613en_US
dc.identifier.issn0365-0596
dc.identifier.issn1806-4841
dc.identifier.issue5en_US
dc.identifier.pmid27828634en_US
dc.identifier.scopus2-s2.0-84994651519en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage611en_US
dc.identifier.urihttps://doi.org/10.1590/abd1806-4841.20164766
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11154
dc.identifier.volume91en_US
dc.identifier.wosWOS:000388465100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Brasileira Dermatologiaen_US
dc.relation.ispartofAnais Brasileiros De Dermatologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethylenetetrahydrofolate Reductase (NADPH2)en_US
dc.subjectPolymorphismen_US
dc.subjectsingle nucleotideen_US
dc.subjectPsoriasisen_US
dc.subjectTurkeyen_US
dc.titleMethylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkeyen_US
dc.typeArticleen_US

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