Lidocaine for prevention of propofol injection-induced pain

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dc.contributor.authorKaya, Sedat
dc.contributor.authorTurhanoglu, Selim
dc.contributor.authorKaraman, Haktan
dc.contributor.authorOzgun, Sule
dc.contributor.authorBasak, Nihal
dc.date.accessioned2024-09-18T20:28:09Z
dc.date.available2024-09-18T20:28:09Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND: Many patients experience pain on injection of propofol. The use of lidocaine to prevent propofol injection pain is common. The analgesic effect of preinjected lidocaine has been found to increase when a tourniquet is used. OBJECTIVE: The aim of this study was to compare the effectiveness of various venous occlusion times with lidocaine analgesia to prevent pain during propofol injection. METHODS: In this prospective, randomized, double-blind, controlled study, women aged 18 to 45 years,, classified as American Society of Anesthesiologists physical status I or II, who were scheduled to undergo elective surgery under general anesthesia induced with propofol, were randomly assigned to 1 of 5 groups: group 1, 2% lidocaine 20 mg in saline in a total volume of 10 mL and no venous occlusion; group 2, 2% lidocaine 20 mg in saline in a total volume of 10 mL plus venous occlusion for 15 seconds; group 3, 296 lidocaine plus venous occlusion for 30 seconds; group 4, 2% lidocaine plus venous occlusion for 60 seconds; and group 5, saline 10 mL and no venous occlusion. When the first 25% of the calculated propofol dose was administered, patients were asked about propofol-induced pain using a verbal pain scale (0 = no pain; 1 = mild pain; 2 = moderate pain; and 3 = severe pain). All patients and the anesthesiologist who evaluated pain severity were blinded to the study preparation being used. RESULTS: The study comprised 100 women who were randomly divided into 5 groups of 20 patients each. Significantly more patients in group 5 (18 [90%] patients; P < 0.05) reported pain compared with the other treatment groups. In groups 2, 3, and 4, in which venous occlusion was applied, pain was reported during propofol injection in 6 (3096), 7 (35%), and 2 (10%) patients, respectively. The incidence of reported pain was significantly greater in group 1 (lidocaine without venous occlusion) than in group 4 (P < 0.05); however, the incidence of pain was similar in group I compared with groups 2 and 3. CONCLUSIONS: The present study found that pretreatment with lidocaine 20 mg with or without venous occlusion significantly reduced the incidence and the severity of pain during the injection of propofol when compared with the group with no venous occlusion administered saline. In addition, pretreatment with lidocaine 20 mg plus venous occlusion for 60 seconds significantly reduced the incidence of propofol-induced pain compared with lidocaine without venous occlusion.en_US
dc.identifier.doi10.1016/j.curtheres.2008.02.005
dc.identifier.endpage35en_US
dc.identifier.issn0011-393X
dc.identifier.issn1879-0313
dc.identifier.issue1en_US
dc.identifier.pmid24692780en_US
dc.identifier.scopus2-s2.0-41249097804en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2008.02.005
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10765
dc.identifier.volume69en_US
dc.identifier.wosWOS:000254223200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectintravenous anestheticen_US
dc.subjectpropofolen_US
dc.subjectcomplicationen_US
dc.subjectpainen_US
dc.subjectlocal anestheticen_US
dc.subjectlidocaineen_US
dc.subjectvenous occlusionen_US
dc.titleLidocaine for prevention of propofol injection-induced painen_US
dc.typeArticleen_US

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