The evaluation of early stage oxidative status in streptozotocin induced diabetes in rats

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dc.authoridKISACAM, Mehmet Ali/0000-0003-0521-9434
dc.contributor.authorKisacam, Mehmet Ali
dc.contributor.authorKocamuftuoglu, Gonca Ozan
dc.contributor.authorUfat, Hakan
dc.contributor.authorOzan, Sema Temizer
dc.date.accessioned2024-09-18T20:15:10Z
dc.date.available2024-09-18T20:15:10Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEarly-stage diabetes can be defined as the stages before absolute insulin deficiency in patients. In this study, the early stage oxidative effect of streptozotocin(STZ) induced diabetes mellitus was evaluated. 28 male adult Sprague-Dawley rats were divided into four groups; control group and 7th, 14th, 21st days diabetic groups. Diabetic groups received single 65 mg/kg STZ injection intraperitoneally. Rats were decapitated at 7th, 14th and 21st days, liver tissues were taken. Nitric oxide(NO), malondialdehyde(MDA) levels and catalase, arginase activities were measured. MDA and NO levels were increased (respectivelyp < .001 andp < .01), mainly 14 and 21 days after STZ administration; moreover, while liver catalase activity was progressively decreased (p < .001), oppositely arginase was increased in the same time period (p < .01). Results show that MDA and nitric oxide together with catalase and arginase switch at an early stage of diabetes and they may contribute to subsequent complications related to diabetes via increased oxidative damage.en_US
dc.identifier.doi10.1080/13813455.2020.1776736
dc.identifier.endpage1478en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue6en_US
dc.identifier.pmid32521173en_US
dc.identifier.scopus2-s2.0-85087030591en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1474en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2020.1776736
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9485
dc.identifier.volume128en_US
dc.identifier.wosWOS:000544824700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectnitric oxideen_US
dc.subjectmalondialdehydeen_US
dc.subjectarginaseen_US
dc.subjectcatalaseen_US
dc.titleThe evaluation of early stage oxidative status in streptozotocin induced diabetes in ratsen_US
dc.typeArticleen_US

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