Nitric oxide levels and superoxide dismutase enzyme activity in synovial fluid of patients with knee osteoarthritis

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dc.contributor.authorKalacı, Aydıner
dc.contributor.authorUz, Efkan
dc.contributor.authorAslan, Bahadir
dc.contributor.authorSoeguet, Sadik
dc.contributor.authorOezkan, Cenk
dc.contributor.authorYanat, Ahmet Nedim
dc.date.accessioned2024-09-18T20:08:04Z
dc.date.available2024-09-18T20:08:04Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: We investigated nitric oxide (NO) levels and superoxide dismutase (SOD) enzyme activity in synovial fluid of patients with primary knee osteoarthritis (OA). Patients and methods: The study included 36 patients (31 females, 5 males; mean age 63 years; range 48 to 88 years) with knee OA according to the diagnosis criteria of American College of Rheumatology. Radiographic severity of OA was assessed according to the Kellgren-Lawrence grading system. Synovial fluid samples were taken by needle aspiration before knee arthroplasty or hyaluronic acid injection and stored at -80 degrees C in Eppendorf tubes. Nitrite and nitrate levels were determined by the spectrophotometric method based on the Griess reaction. Total SOD activity was determined by the spectrophotometric method. The results were compared with those of 10 controls (6 females, 4 males; mean age 49 years; range 26 to 70 years) who clinically and radiographically had normal knees, but underwent arthroscopic examination for knee pain of unknown origin. Results: Compared to controls, NO levels were significantly higher and SOD activity was significantly lower in patients with OA (p < 0.001). No significant differences were found between radiographically graded groups with regard to NO level and SOD activity (p > 0.05). Conclusion: Our data suggest that NO acts as a potent mediator of cartilage damage and SOD as an antioxidant mediator in OA. Further studies are needed to clarify the clinical significance of these parameters.en_US
dc.identifier.endpage17en_US
dc.identifier.issn1305-8282
dc.identifier.issn1309-0313
dc.identifier.issue1en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8591
dc.identifier.volume18en_US
dc.identifier.wosWOS:000253939600003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofEklem Hastaliklari Ve Cerrahisi-Joint Diseases and Related Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcartilage articularen_US
dc.subjectnitric oxideen_US
dc.subjectosteoarthritis kneeen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectsynovial fluiden_US
dc.titleNitric oxide levels and superoxide dismutase enzyme activity in synovial fluid of patients with knee osteoarthritisen_US
dc.typeArticleen_US

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