Upper Zone of Growth Plate and Cartilage Matrix (UCMA) Levels in Patients with Chronic Kidney Disease

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dc.authoridTURGUT, FARUK/0000-0003-1910-7433
dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.authoridozcan, oguzhan/0000-0001-7486-503X
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorDogan, Serdar
dc.contributor.authorArpaci, Abdullah
dc.contributor.authorTurgut, Faruk Hilmi
dc.date.accessioned2024-09-18T20:08:26Z
dc.date.available2024-09-18T20:08:26Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractChronic kidney disease (CKD) is an important health problem across the world affecting the adult population with an enormous social and economic burden. Calcium regulation is also affected in patients with CKD, and related to several disorders including vascular calcifications, mineral bone disorders, and cardiovascular diseases (CVD). Upper zone of growth plate and cartilage matrix (UCMA) is vitamin K-dependent protein (VKDP) and acts as a calcification inhibitor in the cardiovascular system. The molecular mechanism of UCMA action remains unclear in CKD. In the current study, we aimed to investigate serum total UCMA levels and its association with calcium metabolism parameters in CKD patients including hemodialysis (HD) patients. Thirty-seven patients with CKD stage 3-5, 41 HD patients, and 34 healthy individuals were enrolled in this cross-sectional study. Serum UCMA and calcification related protein levels (Matrix Gla Protein (MGP), Osteocalcin (OC), and Fetuin-A) were analyzed with enzyme-linked immunosorbent assay (ELISA). Calcium mineral disorder parameters (Serum Ca, P, iPTH) were quantified with routine techniques. We, for the first time, report the potential biomarker role of UCMA in CKD including HD. Serum total UCMA levels were significantly higher in patients with CKD including HD patients than the healthy controls. Also, serum UCMA levels showed negative correlations with serum calcium, and eGFR, while showed positive relationships with P, iPTH, MGP, OC. Increased total UCMA levels may have a role in the Ca metabolism disorder and related to the pathogenesis of Vascular Calcification in patients with CKD.en_US
dc.description.sponsorshipScientific Research Project Fund of Hatay Mustafa Kemal University [18]en_US
dc.description.sponsorshipThis work is supported by the Scientific Research Project Fund of Hatay Mustafa Kemal University under project number 18.M.063.en_US
dc.identifier.doi10.1590/1678-4324-2020190594
dc.identifier.issn1516-8913
dc.identifier.issn1678-4324
dc.identifier.scopus2-s2.0-85089809752en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/1678-4324-2020190594
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8829
dc.identifier.volume63en_US
dc.identifier.wosWOS:000557798700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInst Tecnologia Paranaen_US
dc.relation.ispartofBrazilian Archives of Biology and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectchronic kidney diseaseen_US
dc.subjecthemodialysisen_US
dc.subjectUCMAen_US
dc.subjectGRPen_US
dc.subjectMGPen_US
dc.subjectOCen_US
dc.titleUpper Zone of Growth Plate and Cartilage Matrix (UCMA) Levels in Patients with Chronic Kidney Diseaseen_US
dc.typeArticleen_US

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