Insufficient decontamination in Sewage treatment plants induce the risk of artificial selection of extended-spectrum ?-lactamase producing Escherichia coli

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dc.contributor.authorGundogdu, A.
dc.contributor.authorKilic, H.
dc.contributor.authorKurekci, C.
dc.contributor.authorAlp, E.
dc.date.accessioned2024-09-18T20:19:51Z
dc.date.available2024-09-18T20:19:51Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractQuantitative data about extended-spectrum beta-lactamase producing E. coli ( ESBLEC) in the wastewaters are scarce, especially in developing countries. These data could be useful to raise awareness about the potential risk of spreading ESBLEC strains in the community. Water samples were collected weekly over a 10-week period, from one urban sewage treatment plant(STP), one rural STP and one hospital complex's wastewater(HWW) in Turkey. Mean E. coli and ESBLEC loads were determined for each sampling point. For the 580 ESBLEC isolated, antimicrobial resistance profiles, phylogenetic grouping, presence of common beta-lactamese-typesand integrons were studied using PCR. The mean ESBLEC ratio was accounted for 0.58%, 0,12%, 1.53% of the total E. coli in urban, rural untreated wastewater and HWW, respectively. These values were higher for the outlets. The mean number of different antimicrobial classes to which the strains were resistant was highest in urban STP(4.0 +/- 1.6). The antimicrobial resistance ratios of ESBLEC strains isolated from HWW were observed to be in between those of urban and rural STPs. The most common phylogenetic group was C composing(29.7%) and the most susceptible strains belonged to phylogroup B1. Wastewater treatments without sufficient decontamination, resulting in artificial selection of ESBLEC might lead to public health risk as these strains reach communities through environment. To avoid such risks and protect the human health as well as the environment, well-established decontamination measures imposing barriers against this artificial selection should be implemented.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114S893]; Research Fund of the Erciyes University [TCD-2016-6041]en_US
dc.description.sponsorshipThis work were supported by The Scientific and Technological Research Council of Turkey (TUBITAK-Grand number: 114S893) and by The Research Fund of the Erciyes University (Project Number: TCD-2016-6041).en_US
dc.identifier.doi10.14715/cmb/2017.63.9.15
dc.identifier.endpage86en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue9en_US
dc.identifier.pmid28980926en_US
dc.identifier.scopus2-s2.0-85030546840en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2017.63.9.15
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9898
dc.identifier.volume63en_US
dc.identifier.wosWOS:000418148100015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectESBL-producing E. colien_US
dc.subjectSewage treatment plantsen_US
dc.subjectHospital wastewateren_US
dc.subjectPhylogenetic groupingen_US
dc.subjectIntegronsen_US
dc.titleInsufficient decontamination in Sewage treatment plants induce the risk of artificial selection of extended-spectrum ?-lactamase producing Escherichia colien_US
dc.typeArticleen_US

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