The association between methylation levels of targeted genes and albuminuria in patients with early diabetic kidney disease

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dc.authoridTURGUT, FARUK/0000-0003-1910-7433
dc.contributor.authorAldemir, Ozgur
dc.contributor.authorTurgut, Faruk
dc.contributor.authorGokce, Cumali
dc.date.accessioned2024-09-18T21:00:27Z
dc.date.available2024-09-18T21:00:27Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The incidence of diabetes and its complications are greatly increasing world-wide. Diabetic nephropathy (DN) is the main cause of end-stage renal disease and is associated with high morbidity and mortality. It is important to predict patients with high risk for DN in the early stage. We selected the genes which have an important role on diabetic kidney disease. We aimed to investigate the association between DNA methylation levels of targeted genes and albuminuria in patients with early DN. Methods: We collected the clinical data of patients with type 2 diabetes mellitus. We measured spot urine albumin creatinine ratio to calculate albuminuria level. We divided patients into two groups based on albumin excretion as patients with (n = 69) and without DN (n = 27). We performed methylation profiling after bisulfite conversion by pyrosequencing method. The mean value of percent methylation level of each gene was calculated. Results: We compared targeted genes (TIMP-2, AKR1B1, MMP-2, MMP-9, MYL9, SCL2A4, SCL2A1, SCL4A3) methylation levels and albuminuria. We found significant negative correlation between TIMP-2 and AKR1B1 gene methylation levels and albuminuria levels. Conclusions: The present study provided evidence that hypomethylation of TIMP-2 and AKR1B1 genes can be associated with albuminuria in patients with early DN. We may speculate that the hypomethylation of TIMP-2 and AKR1B1 genes may be an early surrogate marker of DN.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-3001, 214S378]en_US
dc.description.sponsorshipThe study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK-3001); The Grant number: 214S378.en_US
dc.identifier.doi10.1080/0886022X.2017.1358180
dc.identifier.endpage601en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1en_US
dc.identifier.pmid28805547en_US
dc.identifier.scopus2-s2.0-85044147393en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://doi.org/10.1080/0886022X.2017.1358180
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12695
dc.identifier.volume39en_US
dc.identifier.wosWOS:000418638200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectType 2 diabetesen_US
dc.subjectdiabetic nephropathyen_US
dc.subjectmicroalbuminuriaen_US
dc.subjectTIMP-2en_US
dc.subjectAKR1B1 methylationen_US
dc.titleThe association between methylation levels of targeted genes and albuminuria in patients with early diabetic kidney diseaseen_US
dc.typeArticleen_US

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