Asymptomatic herpes simplex virus type 2 (HSV-2) infection among pregnant women in Turkey

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dc.authoridYarkin, Fugen/0000-0002-6012-2320
dc.contributor.authorDuran, N
dc.contributor.authorYarkin, F
dc.contributor.authorEvruke, C
dc.contributor.authorKoksal, F
dc.date.accessioned2024-09-18T20:08:08Z
dc.date.available2024-09-18T20:08:08Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground & objectives: A large proportion of individuals with serologic evidence of infection with herpes simplex virus type 2 (HSV-2) are asymptomatic. HSV-2 is the main cause of genital herpes infections. The acquisition of genital herpes during pregnancy has been associated with spontaneous abortion, premature labour and congenital and neonatal herpes. The present study was undertaken to determine asymtomatic genital HSV-2 shedding and seroprevalence of HSV-2 infection among asymptomatic pregnant women at the time of delivery in Adana, Turkey. Methods: Asymptomatic 130 pregnant women without a history of genital herpes were enrolled in the study. HSV-2 shedding was determined by viral culture of the swabs collected from cervix and vulva and HSV-2 antigen was detected by direct immunofluorescence assay (IFA), HSV-2 IgG and IgM antibodies were detected by HSV-2 type specific IgG and IgM enzyme-linked immunosorbent assay (ELISA). Results: HSV-2 IgG and IgM antibodies were found in 82 (63.1%) and 18 (11.3%) of 130 pregnant women. HSV-2 type-specific antigen was detected in 22 (16.9%) pregnant women by IFA test, 17 (13.1%) of whom had HSV-2 IgM antibodies. HSV-2 was isolated only in 3 women. Interpretation & conclusion: The seroprevalence of HSV-2 (63.1%) and genital HSV-2 infection (16.9%) was high among asymptomatic pregnant women in Adana, Turkey. Therefore, to reduce the risk of neonatal herpes, HSV-2 type-specific antibodies should be detected in pregnant women using serological tests that allow to identify women with asymptomatic or subclinical genital HSV-2 infection and those susceptible to primary genital HSV-2 infection.en_US
dc.identifier.endpage110en_US
dc.identifier.issn0971-5916
dc.identifier.issue2en_US
dc.identifier.pmid15347860en_US
dc.identifier.scopus2-s2.0-4544346030en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage106en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8660
dc.identifier.volume120en_US
dc.identifier.wosWOS:000223870000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcell cultureen_US
dc.subjectELISAen_US
dc.subjectgenital herpesen_US
dc.subjectherpes simplex virus type 2en_US
dc.subjectIFAen_US
dc.subjectpregnant womenen_US
dc.subjectseroprevalenceen_US
dc.titleAsymptomatic herpes simplex virus type 2 (HSV-2) infection among pregnant women in Turkeyen_US
dc.typeArticleen_US

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