Thiol/disulfide homeostasis as a new oxidative stress marker in patients with neonatal transient tachypnea

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dc.authoridDemirtas, Mehmet Semih/0000-0003-2965-1811
dc.authoridErdal, Huseyin/0000-0003-0786-5077
dc.contributor.authorErdal, Huseyin
dc.contributor.authorDemirtas, Mehmet Semih
dc.contributor.authorTuncer, Sibel Cigdem
dc.contributor.authorOzcan, Oguzhan
dc.date.accessioned2024-09-18T21:00:22Z
dc.date.available2024-09-18T21:00:22Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.descriptionInternational Congress on Innovative Approaches in Medical and Health Sciences -- 2022 -- ELECTR NETWORKen_US
dc.description.abstractAim: Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress occurring in delayed clearance of lung fluid. This is the first report to examine thiol-disulfide homeostasis in patients with TTN.Material and Methods: Thirty TTN and 30 controls were included in the present study. The dynamic thiol-disulfide balance was determined by the new colorimetric method developed by Erel et al. TAS, TOS and OSI levels were evaluated using the previously described method developed by Erel.Results: Thiol levels were found to be significantly lower between patient and the control groups. However, disulfide levels were not significantly higher in the TTN group compared with the control groups. Disulfide/native thiol, disulfide/total thiol and native/total thiol levels were statistically significantly different between the TTN and control groups. Moreover, we found that TAS, TOS and OSI levels were also statistically significantly different between patient and control groups.Discussion: This study indicates that the measurement of dynamic thiol-disulfide homeostasis may contribute to the pathophysiological mechanism, and follow-up of the disease in patients with TTN. In addition, increased TOS and decreased TAS levels may be related with increased oxidative stress and a functional reduction of antioxidant defense systemen_US
dc.description.sponsorshipAksaray University Coordination Office of Scientific Research Projects [2021-019]en_US
dc.description.sponsorshipFunding: This research was supported by Aksaray University Coordination Office of Scientific Research Projects (Project #2021-019) .en_US
dc.identifier.doi10.4328/ACAM.21457
dc.identifier.endpage211en_US
dc.identifier.issn2667-663X
dc.identifier.issue3en_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.21457
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12625
dc.identifier.volume14en_US
dc.identifier.wosWOS:000952377800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTransient Tachypneaen_US
dc.subjectOxidative Stressen_US
dc.subjectThiolen_US
dc.subjectDisulfide Homeostasisen_US
dc.subjectNewbornen_US
dc.subjectRespiratory Distressen_US
dc.titleThiol/disulfide homeostasis as a new oxidative stress marker in patients with neonatal transient tachypneaen_US
dc.typeConference Objecten_US

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