Age-related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep

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dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridCeyhan, Hatice Rumeysa/0000-0001-9239-5537
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.contributor.authorCoskun, Devran
dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorCetin, Gul
dc.contributor.authorIrmak, Mehmet
dc.contributor.authorCeyhan, Hatice Rumeysa
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-09-18T19:52:30Z
dc.date.available2024-09-18T19:52:30Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe pharmacokinetics of meloxicam was studied in 1-, 6-, and 12-month- old sheep following a single intravenous (i.v.) dose of 1 mg/kg. The experiments were carried out when the Romanov sheep were 1 month old (7.93 +/- 0.91 kg), 6 months old (27.47 +/- 4.91 kg), and 12 months old (37.10 +/- 3.64 kg). Meloxicam concentration in plasma was determined by high-performance liquid chromatography and the data collected were evaluated by non-compartmental kinetic analysis. Meloxicam was detected in the plasma up to 72 h following i.v. administration in all age groups. The volume of distribution at steady state (Vdss) and total body clearance (ClT) were significantly higher in 1- month- old (304.87 mL/kg and 16.57 mL/h/kg) than in 12- month- old (193.43 mL/kg and 10.50 mL/h/kg) sheep. The area under the concentration- time curve from 0 to 72 h value of meloxicam was lower in 1- month- old (58.51 h*mu g/mL) compared to 12- month- old (92.59 h*mu g/mL) sheep. There was no difference in t1/ 2.z value in different age groups. The body extraction ratio values for meloxicam ranged from 0.0186 to 0.0719 after i.v. administration in all age groups. Meloxicam showed an increase in plasma concentration and a decrease in Vdss and ClT in 12- month- old compared to 1- month- old sheep. Compared to 1- month- old and 12- month- old sheep, there was no difference in these parameters in 6- month- old sheep. Because the age of sheep has an influence on the pharmacokinetics of meloxicam, dosage apparently may need to be adjusted for age.en_US
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Erzincan Binali Yildirim, Turkiyeen_US
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Erzincan Binali Yildirim, Turkiyeen_US
dc.identifier.doi10.1111/jvp.13404
dc.identifier.endpage331en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue5en_US
dc.identifier.pmid37488663en_US
dc.identifier.startpage326en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.13404
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7465
dc.identifier.volume46en_US
dc.identifier.wosWOS:001035604200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectage-related pharmacokineticsen_US
dc.subjectHPLCen_US
dc.subjectintravenousen_US
dc.subjectmeloxicamen_US
dc.subjectsheepen_US
dc.titleAge-related changes in the pharmacokinetics of meloxicam after intravenous administration in sheepen_US
dc.typeArticleen_US

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