The genotoxic and antigenotoxic effects of tannic acid in human lymphocytes

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dc.authoridBuyukleyla, Mehmet/0000-0002-4450-2710
dc.contributor.authorBuyukleyla, Mehmet
dc.contributor.authorAzirak, Sebile
dc.contributor.authorRencuzogullari, Eyyup
dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorIla, Hasan Basri
dc.contributor.authorTopaktas, Mehmet
dc.contributor.authorDarici, Cengiz
dc.date.accessioned2024-09-18T20:59:16Z
dc.date.available2024-09-18T20:59:16Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe genotoxicity of tannic acid (TA, tannin) were investigated using chromosome aberration (CA), sister chromatid exchange (SCE), and micronucleus (MN) test systems in human peripheral lymphocytes. Also, the antigenotoxicity of TA against known mutagen EMS was also examined. The lymphocytes were treated with 1.74 x 10(-5), 3.49 x 10(-5), and 6.98 x 10(-5) mu M of TA for 24- and 48-hour treatment periods. For the antigenotoxicity of TA, the lymphocytes were treated with three different concentrations of TA and 2.71 mu M of EMS. TA synergically induced the CA alone and with the mixture of EMS. However, TA did not induce the SCE alone, whereas TA and EMS as a mixture also synergically induced SCE. TA alone showed no clear effect on micronucleus formation, and it did not induce the MN when used with EMS as a mixture. In addition, TA showed a synergistic cytotoxic effect by decreasing the mitotic and nuclear division indices. The replication index was decreased at all concentrations for 48 hours of treatment time by TA and EMS as a mixture.en_US
dc.description.sponsorshipCukurova University [FEF2007BAP4]en_US
dc.description.sponsorshipThis study was funded by the Cukurova University Research Fund (FEF2007BAP4).en_US
dc.identifier.doi10.3109/01480545.2011.564181
dc.identifier.endpage19en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue1en_US
dc.identifier.pmid21774736en_US
dc.identifier.scopus2-s2.0-83155193488en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.3109/01480545.2011.564181
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12490
dc.identifier.volume35en_US
dc.identifier.wosWOS:000297758200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTannic aciden_US
dc.subjectgenotoxicityen_US
dc.subjectantigenotoxicityen_US
dc.subjecthuman lymphocytesen_US
dc.titleThe genotoxic and antigenotoxic effects of tannic acid in human lymphocytesen_US
dc.typeArticleen_US

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