The Relationship Between the Neuron Density of the Trigeminal Ganglion and the Posterior Communicating Artery Vasospasm in Subarachnoid Hemorrhage: An Experimental Study

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dc.authoridRECEP, AYGUL/0000-0002-3603-2480
dc.authoridKanat, Ayhan/0000-0002-8189-2877
dc.authoridKOTAN, DILCAN/0000-0002-3101-4742
dc.authoridGundogdu, Cemal/0000-0003-2857-923X
dc.contributor.authorAydin, Mehmet Dumlu
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorGundogdu, Cemal
dc.contributor.authorAydin, Nazan
dc.contributor.authorAygul, Recep
dc.contributor.authorKotan, Dilcan
dc.contributor.authorUlvi, Hizir
dc.date.accessioned2024-09-18T21:00:23Z
dc.date.available2024-09-18T21:00:23Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Posterior communicating arteries (PComAs) are innervated by vasodilatatory fibers of the trigeminal ganglion (TGG). We examined whether there is a relationship between the neuron density of the TGG and the severity of PComA vasospasm in a subarachnoid hemorrhage (SAH). Methods: This study was conducted on 20 rabbits. Five were used as a baseline control group. Five were used as a sham group by injecting 1 mL of serum physiologic, and experimental SAH was applied to 10 animals by injecting homologous blood into the cisterna magna. After 10 days, PComAs and TGGs were examined histopathologically. PComA volumes and the neuron density of TGGs were estimated stereologically, and the results were analyzed statistically. Results: In control group, the mean volume of the PComAs was 66,500 +/- 8500 mu m(3), and the mean neuronal density of the TGGs was 8650 +/- 950/mm(3). In the serum physiologic group, the mean volume of the PComAs was 65,000 +/- 6550 mu m(3), and the mean neuronal density of the TGGs was 8600 +/- 800/mm(3). In the SAH group, the mean volume of the PComAs was 46,500 +/- 5500 mu m(3), and the mean neuronal density of the TGGs was 4200 +/- 500/mm(3). The results reveal an inverse relationship between the neuronal density in the TGG and the severity of the PComA vasospasm. Conclusions: The neuron density of the TGG may be an important factor in the regulation of PComA volume and in the continuation of cerebral blood flow. Low neuron density in the TGG may play an important role in the pathogenesis of PComA vasospasm in SAH.en_US
dc.identifier.doi10.1097/WNQ.0b013e3182011683
dc.identifier.endpage6en_US
dc.identifier.issn1050-6438
dc.identifier.issn1534-4916
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84857167139en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1097/WNQ.0b013e3182011683
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12650
dc.identifier.volume22en_US
dc.identifier.wosWOS:000300408500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNeurosurgery Quarterlyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttrigeminal ganglionen_US
dc.subjectneuron densityen_US
dc.subjectposterior communicating arteryen_US
dc.subjectvasospasmen_US
dc.subjectsubarachnoid hemorrhageen_US
dc.titleThe Relationship Between the Neuron Density of the Trigeminal Ganglion and the Posterior Communicating Artery Vasospasm in Subarachnoid Hemorrhage: An Experimental Studyen_US
dc.typeArticleen_US

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