Influence of carbenoxolone on the anticonvulsant efficacy of phenytoin in pentylenetetrazole kindled rats

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dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.authoridACAR KARAKURT, Meryem Dilek/0000-0002-2314-8126
dc.contributor.authorSefil, Fatih
dc.contributor.authorBagirici, Faruk
dc.contributor.authorAcar, M. Dilek
dc.contributor.authorMarangoz, Cafer
dc.date.accessioned2024-09-18T20:06:28Z
dc.date.available2024-09-18T20:06:28Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAbnormal synchronized neuronal discharges mediated by gap junctions have an important role in epileptic seizures. The analysis of anticonvulsant drugs acting on gap junctions is still a priority in epilepsy research. Therefore, the present study was designed to investigate the effect of carbenoxolone, a gap junction blocker, on the anticonvulsant efficacy of phenytoin in pentylenetetrazole kindled rats. Male Wistar albino rats, 14 weeks of age, were used. In the first step of the study, animals were given PTZ 35 mg/kg intraperitoneally (i.p.) three times a week until kindling was produced. Then, indwelling screw electrodes - allowing EEG monitoring of conscious rats - were implanted into the crania of the kindled rats. In this way, we were able to record EEG activity and evaluate seizure stage at the same time. In the second step of the study, the interaction between carbenoxolone (40 mg/kg i.p.) and phenytoin (60 mg/kg, i.p.) was investigated. The data analysis was performed using a one-way ANOVA with LSD post-hoc test. Total spike number and the generalized seizure duration were reduced in the carbenoxolone treated group compared to the PTZ group. Phenytoin decreased generalized seizure duration, total spike number and seizure severity score. Carbenoxolone and phenytoin have anti-seizure effects in PTZ kindled rats. There was no significant difference between the carbenoxolone + phenytoin combination and phenytoin in terms of generalized seizure duration, total spike number and seizure stage. The results indicate that carbenoxolone combined with phenytoin is not more effective than the use of these drugs alone.en_US
dc.description.sponsorshipOndokuz Mayis University Research Foundation [PYO. TIP.1904.09.010]en_US
dc.description.sponsorshipThis project was supported by the Ondokuz Mayis University Research Foundation (PYO. TIP.1904.09.010).en_US
dc.identifier.endpage184en_US
dc.identifier.issn0065-1400
dc.identifier.issue2en_US
dc.identifier.pmid22810219en_US
dc.identifier.scopus2-s2.0-84864763952en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8539
dc.identifier.volume72en_US
dc.identifier.wosWOS:000306631200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNencki Inst Experimental Biologyen_US
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcarbenoxoloneen_US
dc.subjectphenytoinen_US
dc.subjectgap junctionen_US
dc.subjectpentylenetetrazole kindlingen_US
dc.titleInfluence of carbenoxolone on the anticonvulsant efficacy of phenytoin in pentylenetetrazole kindled ratsen_US
dc.typeArticleen_US

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