The evaluation of SIRS status with hemato-biochemical indices in bitches affected from pyometra and the Usefulness of these indices as a potential diagnostic tool

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dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.contributor.authorYazlik, Murat Onur
dc.contributor.authorMutluer, Ipek
dc.contributor.authorYildirim, Mehmet
dc.contributor.authorKaya, Ufuk
dc.contributor.authorColakoglu, Hatice Esra
dc.contributor.authorVural, Mehmet Rifat
dc.date.accessioned2024-09-18T20:04:35Z
dc.date.available2024-09-18T20:04:35Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aims of this study were to establish a cut-off point by evaluating the usability of the hemato-biochemical indices to determine the severity of inflammation caused by pyometra, and to determine the practical usage of the indices as a diagnostic biomarker in cases of pyometra. Animals that were admitted to Ankara University Veterinary Faculty Obstetrics and Gynecology Clinic were included in the present study. Dogs suffering from pyometra were allocated to two groups according to their SIRS status (SIRS, n = 12; Non-SIRS (NSIRS, n = 16)). Healthy dogs presented for routine ovariohysterectomy were used as the control (n = 13). Blood samples were collected into two tubes containing EDTA for hema-tological analysis and without anticoagulant for biochemical tests before the beginning of treatment. Hemato-biochemical indices, which are Neutrophil-Lymphocyte Ratio (NLR), Monocyte-Lymphocyte Ratio (MLR), Neutrophil Percentage-Albumin Ratio (NPAR), Platelet-Lymphocyte Ratio and Systemic Immune-Inflammation Index, were calculated. All data were analyzed using the MIXED procedure of the SPSS. Receiver operating characteristics curves were used to determine the dog level threshold for evaluating the SIRS status and used to determine a predicted threshold with hemato-biochemical indices for differentiation between dogs with pyometra (regardless of SIRS status) and the control. Pairwise comparisons were carried out of the area under the curve (AUC) for thresholds of SII, NLR, PLR, MLR, NPAR. White blood cells, lymphocytes, monocyte, neutrophil, ALP, NLR, MLR, and NPAR levels were greater in dogs that suffer from SIRS (P < 0.05). Red blood cells and hematocrit levels were significantly higher in the control group (P < 0.05). Albumin levels were higher in the control group (P < 0.05). Moreover, NLR, MLR and NPAR levels were found to be significantly higher in the SIRS group (P < 0.05). Besides, NLR and MLR were the best predictors for diagnosis of the SIRS with the AUC values of 0.936, and 0.966 respectively. Furthermore, NLR, MLR and SII could be a useful diagnostic tool for pyometra with the AUC values of 0.955, 0.931, 0.716. The blood indices could be used as fast, easily accessible, and inexpensive markers for the evaluation of the SIRS status in dogs with pyometra together with diagnosis.(c) 2022 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK), Turkiye [120O543]en_US
dc.description.sponsorshipThe preliminary version of this article was presented as an oral presentation entitled Evaluation of Hemato-biochemical indices in dogs with pyometra that developing SIRS at the IX National and III International Congress of the Turkish Society of Veterinary Gynecology, 24-27 March 2022, Antalya, Turkiye. This study was performed under the project supported by The Scientific and Technological Research Council of Turkiye (TUBITAK) (Project number: 120O543) , Turkiye.en_US
dc.identifier.doi10.1016/j.theriogenology.2022.09.015
dc.identifier.endpage127en_US
dc.identifier.issn0093-691X
dc.identifier.issn1879-3231
dc.identifier.pmid36156424en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.1016/j.theriogenology.2022.09.015
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8265
dc.identifier.volume193en_US
dc.identifier.wosWOS:000862614700014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTheriogenologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood indicesen_US
dc.subjectDogen_US
dc.subjectPyometraen_US
dc.subjectSIRSen_US
dc.titleThe evaluation of SIRS status with hemato-biochemical indices in bitches affected from pyometra and the Usefulness of these indices as a potential diagnostic toolen_US
dc.typeArticleen_US

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