Subclinical Myocardial Injury in Clinically Healthy Obese Dogs

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dc.authoridNASERI, AMIR/0000-0001-9140-5879
dc.authoridERTURK, ALPER/0000-0002-4271-7953
dc.authoridGulersoy, Erdem/0000-0001-8511-0150
dc.authoridDURGUT, MURAT KAAN/0000-0002-4582-8536
dc.contributor.authorNaseri, A.
dc.contributor.authorIder, M.
dc.contributor.authorGulersoy, E.
dc.contributor.authorKoral, E.
dc.contributor.authorErturk, A.
dc.contributor.authorDurgut, M. K.
dc.contributor.authorOk, M.
dc.date.accessioned2024-09-18T20:06:31Z
dc.date.available2024-09-18T20:06:31Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the relationship between obesity and adipokines and also to determine subclinical myocardial injury by cardiac biomarkers. Twenty-five healthy obese (HO) and 15 healthy normal weight (HN) mixed breed dogs were enrolled in the study. Blood sampling and cardiologic examination were performed in all dogs in order to exclude any diseases. The HO group had higher levels of triglycerides (P<0.005), glucose (P<0.025), and lower levels of creatinine (P<0.010) compared to HN dogs. HO dogs had higher serum leptin (P<0.001) but lower adiponectin concentrations (P<0.009) than HN dogs. Systolic blood pressure (P<0.004) and serum concentration of cardiac troponin T was significantly higher in HO dogs compared to HN dogs (P<0.038). There was no statistical significance in concentrations of blood urea nitrogen, alanine aminotransferase, alkaline phosphatase, albumin, total protein, cholesterol, cardiac troponin I, and N-terminal pro brain natriuretic peptide between HO and HN dogs. The bivariate analysis revealed that triglyceride, leptin and systolic blood pressure had positive (r=0.45, P<0.01; r=0.78, P<0.001; r=0.46, P<0.05, respectively) and adiponectin had negative correlation with body condition score (r=-0.39, P<0.05). Cardiac troponin T had a positive correlation with systolic blood pressure (r=0.56, P<0.01). The findings indicate that unfavorable metabolic and lipid changes in obese dogs and systemic hypertension have harmful effects on the myocardium. Elevation of serum cardiac troponin T in obese dogs compared to healthy dogs could represent a probable subclinical myocardial damage in obese dogs.en_US
dc.description.sponsorshipSelcuk University Scientific Research Office [:17401178]en_US
dc.description.sponsorshipThis study was supported by Selcuk University Scientific Research Office (Project no:17401178).en_US
dc.identifier.endpage167en_US
dc.identifier.issn0334-9152
dc.identifier.issn2304-8859
dc.identifier.issue3en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8561
dc.identifier.volume75en_US
dc.identifier.wosWOS:000571645800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIsrael Veterinary Medical Assocen_US
dc.relation.ispartofIsrael Journal of Veterinary Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiac Biomarkersen_US
dc.subjectHypertensionen_US
dc.subjectMetabolic Disorderen_US
dc.subjectTroponinen_US
dc.titleSubclinical Myocardial Injury in Clinically Healthy Obese Dogsen_US
dc.typeArticleen_US

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