Biogenic Nanocopper: Eco-Friendly Synthesis, Characterization, and Their Anti-Trichomonas vaginalis, Anticancer, and Antimicrobial Effects

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dc.authoridaydin, ali/0000-0002-9550-9111
dc.contributor.authorDuran, Beyza
dc.contributor.authorPercin, Eda
dc.contributor.authorAydin, Ali
dc.contributor.authorDesteguel, Ali
dc.contributor.authorAydin, Davut
dc.contributor.authorOezpinar, Necati
dc.contributor.authorKaradag, Ahmet
dc.date.accessioned2024-09-18T19:54:27Z
dc.date.available2024-09-18T19:54:27Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBiogenic nanocopper (BNC) agents exhibit strong anticancer, antimicrobial, and antiparasitic effects. Their fewer side effects to normal cells cause them to be preferred to treat various diseases. Metal nanoparticles, particularly copper nanoparticles, are attracting more significant interest as therapeutic agents with the improvement of green synthesis methods. Studies to reduce the side effects of copper nanoparticles to exhibit strong pharmacological properties are progressing intensively. Here, BNCs with reduced side effects were synthesized using L-ascorbic acid as the reducing agent and various concentrations of copper (II) chloride. BNCs exhibited significant pharmacological activity on cancer, bacteria, and Trichomonas vaginalis cells. The newly synthesized BNCs were characterized by scanning electron microscopy, UV-Vis spectrophotometry, Fourier transform infrared spectroscope, and Differential/Thermal Gravimetric Analysis. The pharmacological activity of BNCs was evaluated by obtaining their inhibitor concentration and minimum inhibitory concentrations against some cancer, bacteria, and T. vaginalis cells. Newly synthesized BNCs have various shapes such as cubic, spherical, or rod and particle size distribution between 70 and 100 nm. According to experiment results, the newly synthesized BNCs were a significantly antiproliferative, antibacterial, and anti-T. vaginalis effect on cells compared to the control drugs. These findings confirm newly synthesized BNCs and their in vitro pharmacological potential. Further research should be targeted on the preclinical study of absorption, distribution, metabolism, excretion/toxicity (ADME/Tox) and in vivo effects on cancer and microbial pathogens.en_US
dc.identifier.doi10.1089/jmf.2021.0151
dc.identifier.endpage792en_US
dc.identifier.issn1096-620X
dc.identifier.issn1557-7600
dc.identifier.issue7en_US
dc.identifier.pmid35834634en_US
dc.identifier.scopus2-s2.0-85134142439en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage787en_US
dc.identifier.urihttps://doi.org/10.1089/jmf.2021.0151
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7749
dc.identifier.volume25en_US
dc.identifier.wosWOS:000827558700011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal of Medicinal Fooden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantibacterialen_US
dc.subjectantiproliferativeen_US
dc.subjectanti-Trichomonas vaginalisen_US
dc.subjectbiogenic nanocopperen_US
dc.subjectcopper (II) chlorideen_US
dc.subjectL-ascorbic aciden_US
dc.titleBiogenic Nanocopper: Eco-Friendly Synthesis, Characterization, and Their Anti-Trichomonas vaginalis, Anticancer, and Antimicrobial Effectsen_US
dc.typeArticleen_US

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