Effect of periodontal disease on oxidative stress markers in patients with atherosclerosis

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dc.authoridSari, Aysegul/0000-0001-6180-9776
dc.authoriderciyas, kamile/0000-0001-9940-0423
dc.contributor.authorSari, Aysegul
dc.contributor.authorDavutoglu, Vedat
dc.contributor.authorBozkurt, Emrullah
dc.contributor.authorTaner, Ibrahim Levent
dc.contributor.authorErciyas, Kamile
dc.date.accessioned2024-09-18T20:54:10Z
dc.date.available2024-09-18T20:54:10Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives The aim of this study was to investigate the effect of periodontal inflammation on oxidative stress in patients with atherosclerosis by considering serum and saliva total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI). Materials and methods In the study, there were 4 groups, with 20 individuals in each group. These groups consisted of individuals who had periodontitis with atherosclerosis (group A-P), were periodontally healthy with atherosclerosis (group A-C), were systemically healthy with periodontitis (group P), and were systemically and periodontally healthy (group C). Clinical periodontal parameters were recorded. PISA values were calculated. Atherosclerosis severity was determined by the Gensini score. The ratio of TAS/TOS resulting in the OSI levels of the serum and saliva samples was examined biochemically. Results Group A-P serum TAS and group C saliva OSI values were lower than those of the other groups (p < 0.05). Group A-P serum TOS and OSI values were higher than those of the other groups (p < 0.05). Groups A-C and P serum TOS and OSI values were higher than those of group C (p < 0.05). In the multivariate linear regression analysis, group A-P and PISA values were independently associated with serum TOS and OSI values (p < 0.05). Group A-P, group P, and PISA values were independently associated with saliva OSI values (p < 0.05). Conclusions Periodontitis and atherosclerosis may have systemic oxidative stress-increasing effects. The coexistence of periodontitis and atherosclerosis increases oxidative stress beyond that seen in either condition alone. Periodontitis can be associated with increased systemic TOS and OSI values in patients with atherosclerosis.en_US
dc.description.sponsorshipGaziantep University [DHF. 14. 07]en_US
dc.description.sponsorshipThe present study was supported by the Gaziantep University Project Number DHF. 14. 07.en_US
dc.identifier.doi10.1007/s00784-021-04144-8
dc.identifier.endpage1724en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue2en_US
dc.identifier.pmid34415433en_US
dc.identifier.scopus2-s2.0-85113137794en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1713en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-021-04144-8
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11641
dc.identifier.volume26en_US
dc.identifier.wosWOS:000686834800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectPeriodontitisen_US
dc.subjectAtherosclerosisen_US
dc.subjectOxidative stressen_US
dc.subjectCardiovascular diseasesen_US
dc.titleEffect of periodontal disease on oxidative stress markers in patients with atherosclerosisen_US
dc.typeArticleen_US

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