Chemopreventive efficacy of juniper berry oil (Juniperus communis L.) on azoxymethane-induced colon carcinogenesis in rat

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dc.authoridkomuroglu, ahmet ufuk/0000-0002-0371-9251
dc.authoridYENER, Zabit/0000-0002-6365-5843
dc.contributor.authorYaman, Turan
dc.contributor.authorUyar, Ahmet
dc.contributor.authorKomuroglu, Ahmet Ufuk
dc.contributor.authorKeles, Omer Faruk
dc.contributor.authorYener, Zabit
dc.date.accessioned2024-09-18T20:11:36Z
dc.date.available2024-09-18T20:11:36Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the chemopreventive effects of juniper berry (JB) oil on azoxymethane (AOM)-induced colon cancer in rats. Thirty-two male Wistar albino rats were allocated into four groups: Control, AOM, AOM?+?JB, and JB groups. Whereas the control group was fed with standard pellet feed, the AOM and AOM?+?JB groups were administered of AOM (15?mg/kg body weight) subcutaneously once every 2 weeks for 10?weeks. AOM?+?JB and JB groups additionally received JB oil (100??l/kg) orally. At the end of the 16-week experimental period, blood and tissue samples were obtained from the rats following necropsy. The macroscopic findings showed that the application of JB oil significantly decreased adenoma and adenocarcinoma formation both numerically and dimensionally. Immunohistochemically, CEA, COX-2, and Ki-67 immune-expressions decreased, and the immune-expression of caspase-3 increased in AOM?+?JB treated rats. Additionally, JB oil supplementation ameliorated antioxidant defense systems and lipid peroxidation within the colon tissue of AOM?+?JB treated rats. These results reveal that the JB oil acted as a chemopreventive dietary agent, inhibiting cell proliferation and COX-2 expression and inducing apoptosis, resulting in a significant reduction in colon tumor formation.en_US
dc.description.sponsorshipVan Yuzuncu Yil University Scientific Research Projects Foundation [TSA-2017-5834]en_US
dc.description.sponsorshipThis research was supported by the Van Yuzuncu Yil University Scientific Research Projects Foundation [Grant number TSA-2017-5834].en_US
dc.identifier.doi10.1080/01635581.2019.1673450
dc.identifier.endpage146en_US
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.issue1en_US
dc.identifier.pmid31617778en_US
dc.identifier.scopus2-s2.0-85074376358en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.1080/01635581.2019.1673450
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8975
dc.identifier.volume73en_US
dc.identifier.wosWOS:000490620600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoutledge Journals, Taylor & Francis Ltden_US
dc.relation.ispartofNutrition and Cancer-An International Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal canceren_US
dc.subjectanimal modelsen_US
dc.subjectantioxidanten_US
dc.subjectcox-inhibitoren_US
dc.subjectapoptosisen_US
dc.subjectflavonoidsen_US
dc.titleChemopreventive efficacy of juniper berry oil (Juniperus communis L.) on azoxymethane-induced colon carcinogenesis in raten_US
dc.typeArticleen_US

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