Pan-Immune-Inflammation Value Is Independently Correlated to Impaired Coronary Flow After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction

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dc.authoridBEKLER, OZKAN/0000-0002-0031-6457
dc.contributor.authorSen, Fatih
dc.contributor.authorKurtul, Alparslan
dc.contributor.authorBekler, Ozkan
dc.date.accessioned2024-09-18T20:33:03Z
dc.date.available2024-09-18T20:33:03Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractImmune-inflammatory biomarkers have been shown to be correlated with impaired coronary flow (ICF) in ST-segment elevation myocardial infarction. In this study, we assessed the relation between a novel comprehensive biomarker, pan-immune-inflammation value (PIV), and ICF after primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction. A total of 687 patients who underwent pPCI between 2019 and 2023 were retrospectively analyzed. Blood samples were collected at admission. PIV and other inflammation parameters were compared. PIV was calculated as (neutrophil count x platelet count x monocyte count)/lymphocyte count. Postprocedural coronary flow was assessed by thrombolysis in myocardial infarction (TIMI) classification. Patients were divided into 2 groups: a group with ICF defined as postprocedural TIMI 0 to 2 and a group with normal coronary flow defined as postprocedural TIMI flow grade of 3. The mean age was 61 +/- 12 years, and 22.4% of the patients were women. Compared with the normal coronary flow group (median 492, interquartile range 275 to 931), the ICF group (median 1,540, interquartile range 834 to 2,909) showed significantly increased PIV (p <0.001). The optimal cutoff for the PIV was 804, as determined by receiver operating characteristic curve. The incidence of ICF was 17.0% in all patients, 6.4% in low-PIV group (<804), and 34.2% in high-PIV group (>= 804). Multivariate analyses revealed that a baseline PIV >= 804 was independently associated with post-pPCI ICF (odds ratio 5.226, p <0.001). PIV was superior to neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in determining ICF. In conclusion, a high-PIV was significantly associated with an increased risk of ICF after pPCI. More-over, PIV was a better indicator of ICF than were other inflammatory markers.(c) 2023 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.amjcard.2023.10.088
dc.identifier.endpage159en_US
dc.identifier.issn0002-9149
dc.identifier.issn1879-1913
dc.identifier.pmid37944774en_US
dc.identifier.scopus2-s2.0-85178137041en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjcard.2023.10.088
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11281
dc.identifier.volume211en_US
dc.identifier.wosWOS:001129075100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherExcerpta Medica Inc-Elsevier Science Incen_US
dc.relation.ispartofAmerican Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmyocardial infarctionen_US
dc.subjectpan-immune-inflammation valueen_US
dc.subjectimpaired coronary flowen_US
dc.titlePan-Immune-Inflammation Value Is Independently Correlated to Impaired Coronary Flow After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarctionen_US
dc.typeArticleen_US

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