Pulmonary hypertension in sickle-cell disease

Basit Öğe Kaydı
dc.contributor.authorAkgul, Ferit
dc.contributor.authorYalcin, Fatih
dc.contributor.authorSeyfeli, Ergun
dc.contributor.authorUcar, Edip
dc.contributor.authorKarazincir, Sinem
dc.contributor.authorBalcı, Ali
dc.contributor.authorGali, Edip
dc.date.accessioned2024-09-18T20:55:33Z
dc.date.available2024-09-18T20:55:33Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Our aim is to determine comorbidities associated with pulmonary hypertension (PHT) in clinically stable sickle-cell disease (SCD) patients and to evaluate left ventricular (LV) and right ventricular (RV) function in those patients. Methods: Echocardiography was performed in 87 SCD patients that were divided into group I (without PHT) and group II (with PHT). Both groups were compared with healthy controls. Results: A history of retinopathy and leg ulcer was more frequent in group II than group I (p < 0.01). Haemoglobin levels were lower (p < 0.05), whereas blood urea nitrogen, lactate dehydrogenase and total bilirubin levels were higher in group II (p < 0.01). Although group II patients had larger LV end-diastolic, LV end-systolic and RV diastolic diameters compared with group I patients and controls (p < 0.05), LV ejection fraction was similar in the three groups. The mitral peak early diastolic inflow velocity to peak late diastolic inflow velocity (E/A) ratio was similar in group I, group II and the control group. The tricuspid E/A ratio was lower in group II than group I and controls (p < 0.05). Conclusion: End organ damage occurs more often and haemolysis is severer in SCD patients with PHT than SCD patients without PHT. Although LV systolic and diastolic function is well preserved, RV diastolic function is disturbed in those patients with PHT. Copyright (c) 2007 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000102588
dc.identifier.endpage60en_US
dc.identifier.issn0001-5792
dc.identifier.issue1en_US
dc.identifier.pmid17505130en_US
dc.identifier.scopus2-s2.0-34347327183en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.1159/000102588
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11915
dc.identifier.volume118en_US
dc.identifier.wosWOS:000246593100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofActa Haematologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpulmonary hypertensionen_US
dc.subjectsickle-cell diseaseen_US
dc.subjectventricular functionen_US
dc.titlePulmonary hypertension in sickle-cell diseaseen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
143.74 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu