Pregabalin does not Cause Midline Closure Defect but is not as Innocent as It is Thought

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dc.contributor.authorSecinti, Kutsal Devrim
dc.contributor.authorEken, Recep
dc.contributor.authorSecinti, Ilke Evrim
dc.contributor.authorYuksel, Kasim Zafer
dc.date.accessioned2024-09-18T20:33:10Z
dc.date.available2024-09-18T20:33:10Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAIM: To investigate the effects of pregabalin on neural tube closure, and other potential effects on other organ systems in a chick embryo model. MATERIAL and METHODS: Fertilized chicken eggs were divided into groups, and different doses of pregabalin was administered. All embryos were harvested in the 8th day of incubation, and investigated both macroscopically and microscopically against any developmental malformations caused by Pregabalin. RESULTS: Macroscopically not any malformations were detected but macrosomia was statistically significant in medium and high dose groups. Microscopically, vertebral lamina ossification was delayed in some embryos in high dose group but not interpreted as midline closure defect and also not statistically significant. Decrease in the number of renal glomerulus and increase in the tubular damage was statistically significant in medium and high dose groups. Cardiomegaly was also found in some embryos in middle and high dose groups but not statistically significant. CONCLUSION: The use of pregabalin does not cause neural tube closure defect in the embryo unless not exceed recommended maximum dose. Causing macrosomia instead of developmental retardation by Pregabalin is in conflict with the literature. This study revealed that Pregabalin causes fetal nephrotoxicity and macrosomia. These findings indicate that the use of Pregabalin in pregnancy still needs to be accounted as suspicious.en_US
dc.description.sponsorshipTurkish Neurosurgical Societyen_US
dc.description.sponsorshipPreparation for publication of this article is partly supported by Turkish Neurosurgical Society.en_US
dc.identifier.doi10.5137/1019-5149.JTN.30907-20.1
dc.identifier.endpage600en_US
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.pmid33978217en_US
dc.identifier.scopus2-s2.0-85110721782en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage594en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.30907-20.1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11337
dc.identifier.volume31en_US
dc.identifier.wosWOS:000672802600016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeural tubeen_US
dc.subjectPregabalinen_US
dc.subjectPregnancyen_US
dc.subjectAvian embryoen_US
dc.subjectNephrotoxicityen_US
dc.titlePregabalin does not Cause Midline Closure Defect but is not as Innocent as It is Thoughten_US
dc.typeArticleen_US

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