Ribosome-binding protein-1 (RRBP1) expression in prostate carcinomas and its relationship with clinicopathological prognostic factors

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dc.contributor.authorKuzuluk, Didar Gursoy
dc.contributor.authorSecinti, Ilke Evrim
dc.contributor.authorErturk, Tugce
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorGorur, Sadik
dc.contributor.authorOzatlan, Dilan
dc.date.accessioned2024-09-18T20:55:30Z
dc.date.available2024-09-18T20:55:30Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduct & imath;on: Studies in recent years have shown that ribosome-binding protein-1 (RRBP1) is expressed at high rates in many cancers and that it may be a potential prognostic biomarker. The objective of the present study is to determine the RRBP1 expression level in prostatic carcinoma and neighboring non-neoplastic prostate tissue, the relationship between its expression level with prognostic factors, and the role of RRBP1 in the development of prostate cancer. Materials and methods: The study included 45 patients who were diagnosed with prostatic carcinoma and underwent radical prostatectomy in our center between the years 2010 and 2021. Pathology reports were reviewed. Mann-Whitney U test was used for the comparison of RRBP1 and GADPH values of the cases (control and tumoral tissue) between the primary tumor stage (pT) and Gleason score (GS) groups. Hierarchical regression analysis was used to explain the effective variables in explaining the RRBP1 value of the research cases Results: According to the Mann-Whitney U test, mean and median RRBP1-T values of the cases with GS >= 8 were detected to be statistically significantly higher than the mean and median RRBP1-T values of the cases with GS < 8. Conclusion: We found out that RRBP1 was expressed at higher rates in patients with high GS and advanced-stage patients. This result indicated that RRBP1 expression may be important in predicting the prognosis of prostate carcinoma.en_US
dc.description.sponsorshipBAP unit of Hatay Mustafa Kemal University [20.M.025]en_US
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the BAP unit of Hatay Mustafa Kemal University by Project number 20.M.025.en_US
dc.identifier.doi10.1177/00369330241245730
dc.identifier.issn0036-9330
dc.identifier.issn2045-6441
dc.identifier.pmid38711311en_US
dc.identifier.scopus2-s2.0-85192369381en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1177/00369330241245730
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11868
dc.identifier.wosWOS:001215191300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofScottish Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate carcinomaen_US
dc.subjectRRBP1en_US
dc.subjectGleason scoreen_US
dc.titleRibosome-binding protein-1 (RRBP1) expression in prostate carcinomas and its relationship with clinicopathological prognostic factorsen_US
dc.typeArticleen_US

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